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Gene Ontology Browser
Term Detail
GO term:necrotic cell death
Synonym: cellular necrosis
Synonym: necrosis
GO id:GO:0070265
Definition:A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.
CommentsNote that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'.
Number of paths to term: 3

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-acell death in response to oxidative stress +
                                        is-anecrotic cell death [GO:0070265] (40 genes, 67 annotations)
                                                negatively-regulatesnegative regulation of necrotic cell death +
                                                part-ofoncosis
                                                positively-regulatespositive regulation of necrotic cell death +
                                                is-aprogrammed necrotic cell death +
                                                regulatesregulation of necrotic cell death +
                                        negatively-regulatesnegative regulation of cell death +
                                        is-aneuron death +
                                        positively-regulatespositive regulation of cell death +
                                        is-aprogrammed cell death +
                                        regulatesregulation of cell death +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-adeath
                                is-acell death
                                        is-acell death in response to oxidative stress +
                                        is-anecrotic cell death [GO:0070265] (40 genes, 67 annotations)
                                                negatively-regulatesnegative regulation of necrotic cell death +
                                                part-ofoncosis
                                                positively-regulatespositive regulation of necrotic cell death +
                                                is-aprogrammed necrotic cell death +
                                                regulatesregulation of necrotic cell death +
                                        negatively-regulatesnegative regulation of cell death +
                                        is-aneuron death +
                                        positively-regulatespositive regulation of cell death +
                                        is-aprogrammed cell death +
                                        regulatesregulation of cell death +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-acell death in response to oxidative stress +
                                        is-anecrotic cell death [GO:0070265] (40 genes, 67 annotations)
                                                negatively-regulatesnegative regulation of necrotic cell death +
                                                part-ofoncosis
                                                positively-regulatespositive regulation of necrotic cell death +
                                                is-aprogrammed necrotic cell death +
                                                regulatesregulation of necrotic cell death +
                                        negatively-regulatesnegative regulation of cell death +
                                        is-aneuron death +
                                        positively-regulatespositive regulation of cell death +
                                        is-aprogrammed cell death +
                                        regulatesregulation of cell death +


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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory