| GO term: | necrotic cell death |
| Synonym: | cellular necrosis |
| Synonym: | necrosis |
| GO id: | GO:0070265 |
| Definition: | A cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. |
| Comments | Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals. |
| Number of paths to term: | 3 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processsingle-organism cellular processcell deathcytolysis +necrotic cell death [GO:0070265] (20 genes, 31 annotations)necrotic cell death in response to starvationnegative regulation of necrotic cell death +oncosispositive regulation of necrotic cell death +programmed necrotic cell death +regulation of necrotic cell death +negative regulation of cell death +neuron death +positive regulation of cell death +programmed cell death +regulation of cell death +biological_processsingle-organism processdeathcell deathcytolysis +necrotic cell death [GO:0070265] (20 genes, 31 annotations)necrotic cell death in response to starvationnegative regulation of necrotic cell death +oncosispositive regulation of necrotic cell death +programmed necrotic cell death +regulation of necrotic cell death +negative regulation of cell death +neuron death +positive regulation of cell death +programmed cell death +regulation of cell death +biological_processsingle-organism processsingle-organism cellular processcell deathcytolysis +necrotic cell death [GO:0070265] (20 genes, 31 annotations)necrotic cell death in response to starvationnegative regulation of necrotic cell death +oncosispositive regulation of necrotic cell death +programmed necrotic cell death +regulation of necrotic cell death +negative regulation of cell death +neuron death +positive regulation of cell death +programmed cell death +regulation of cell death +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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