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Gene Ontology Browser
Term Detail
GO term:archaeal-specific GTP cyclohydrolase activity
Synonym: Fe(2+)-dependent archaeal-specific GTP cyclohydrolase activity
Synonym: MptA activity
GO id:GO:0044682
Definition:Catalysis of the reaction: GTP + H2O <=> 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate +formate + H+. This activity is part of the biosynthesis of methanopterin in Archaea, and requires Fe2+.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-ahydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
                                        is-ahydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
                                                is-acyclohydrolase activity
                                                        is-aGTP cyclohydrolase activity
                                                                is-aarchaeal-specific GTP cyclohydrolase activity [GO:0044682] (6 genes, 6 annotations)
                                                                is-aGTP cyclohydrolase I activity
                                                                is-aGTP cyclohydrolase II activity
                                                                is-aGTP cyclohydrolase IIa activity


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory