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Gene Ontology Browser
Term Detail
GO term:transcription regulatory region DNA binding
GO id:GO:0044212
Definition:Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
CommentsThe word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
Number of paths to term: 4

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding [GO:0044212] (541 genes, 913 annotations)
                                                                is-abacterial-type RNA polymerase regulatory region DNA binding +
                                                                is-acAMP response element binding
                                                                is-acarbohydrate response element binding
                                                                is-acore promoter binding +
                                                                is-acore promoter proximal region DNA binding +
                                                                is-aE-box binding
                                                                is-aenhancer binding +
                                                                is-aestrogen response element binding
                                                                is-aintronic transcription regulatory region DNA binding +
                                                                is-ajuvenile hormone response element binding
                                                                is-amitochondrial heavy strand promoter anti-sense binding
                                                                is-amitochondrial heavy strand promoter sense binding
                                                                is-amitochondrial light strand promoter anti-sense binding
                                                                is-amitochondrial light strand promoter sense binding
                                                                is-amitochondrial RNA polymerase regulatory region DNA binding +
                                                                is-aN-box binding
                                                                is-aplastid RNA polymerase regulatory region DNA binding
                                                                is-apurine-rich negative regulatory element binding
                                                                is-aretinoic acid-responsive element binding
                                                                is-aRNA polymerase I regulatory region DNA binding +
                                                                is-aRNA polymerase II regulatory region DNA binding +
                                                                is-aRNA polymerase III regulatory region DNA binding +
                                                                is-aserum response element binding
                                                                is-asterol response element binding
                                                                is-atranscription regulatory region sequence-specific DNA binding +
                                                                is-atranscription termination site DNA binding +
                                                                is-avitamin D response element binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding [GO:0044212] (541 genes, 913 annotations)
                                                                is-abacterial-type RNA polymerase regulatory region DNA binding +
                                                                is-acAMP response element binding
                                                                is-acarbohydrate response element binding
                                                                is-acore promoter binding +
                                                                is-acore promoter proximal region DNA binding +
                                                                is-aE-box binding
                                                                is-aenhancer binding +
                                                                is-aestrogen response element binding
                                                                is-aintronic transcription regulatory region DNA binding +
                                                                is-ajuvenile hormone response element binding
                                                                is-amitochondrial heavy strand promoter anti-sense binding
                                                                is-amitochondrial heavy strand promoter sense binding
                                                                is-amitochondrial light strand promoter anti-sense binding
                                                                is-amitochondrial light strand promoter sense binding
                                                                is-amitochondrial RNA polymerase regulatory region DNA binding +
                                                                is-aN-box binding
                                                                is-aplastid RNA polymerase regulatory region DNA binding
                                                                is-apurine-rich negative regulatory element binding
                                                                is-aretinoic acid-responsive element binding
                                                                is-aRNA polymerase I regulatory region DNA binding +
                                                                is-aRNA polymerase II regulatory region DNA binding +
                                                                is-aRNA polymerase III regulatory region DNA binding +
                                                                is-aserum response element binding
                                                                is-asterol response element binding
                                                                is-atranscription regulatory region sequence-specific DNA binding +
                                                                is-atranscription termination site DNA binding +
                                                                is-avitamin D response element binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding [GO:0044212] (541 genes, 913 annotations)
                                                                is-abacterial-type RNA polymerase regulatory region DNA binding +
                                                                is-acAMP response element binding
                                                                is-acarbohydrate response element binding
                                                                is-acore promoter binding +
                                                                is-acore promoter proximal region DNA binding +
                                                                is-aE-box binding
                                                                is-aenhancer binding +
                                                                is-aestrogen response element binding
                                                                is-aintronic transcription regulatory region DNA binding +
                                                                is-ajuvenile hormone response element binding
                                                                is-amitochondrial heavy strand promoter anti-sense binding
                                                                is-amitochondrial heavy strand promoter sense binding
                                                                is-amitochondrial light strand promoter anti-sense binding
                                                                is-amitochondrial light strand promoter sense binding
                                                                is-amitochondrial RNA polymerase regulatory region DNA binding +
                                                                is-aN-box binding
                                                                is-aplastid RNA polymerase regulatory region DNA binding
                                                                is-apurine-rich negative regulatory element binding
                                                                is-aretinoic acid-responsive element binding
                                                                is-aRNA polymerase I regulatory region DNA binding +
                                                                is-aRNA polymerase II regulatory region DNA binding +
                                                                is-aRNA polymerase III regulatory region DNA binding +
                                                                is-aserum response element binding
                                                                is-asterol response element binding
                                                                is-atranscription regulatory region sequence-specific DNA binding +
                                                                is-atranscription termination site DNA binding +
                                                                is-avitamin D response element binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding [GO:0044212] (541 genes, 913 annotations)
                                                                is-abacterial-type RNA polymerase regulatory region DNA binding +
                                                                is-acAMP response element binding
                                                                is-acarbohydrate response element binding
                                                                is-acore promoter binding +
                                                                is-acore promoter proximal region DNA binding +
                                                                is-aE-box binding
                                                                is-aenhancer binding +
                                                                is-aestrogen response element binding
                                                                is-aintronic transcription regulatory region DNA binding +
                                                                is-ajuvenile hormone response element binding
                                                                is-amitochondrial heavy strand promoter anti-sense binding
                                                                is-amitochondrial heavy strand promoter sense binding
                                                                is-amitochondrial light strand promoter anti-sense binding
                                                                is-amitochondrial light strand promoter sense binding
                                                                is-amitochondrial RNA polymerase regulatory region DNA binding +
                                                                is-aN-box binding
                                                                is-aplastid RNA polymerase regulatory region DNA binding
                                                                is-apurine-rich negative regulatory element binding
                                                                is-aretinoic acid-responsive element binding
                                                                is-aRNA polymerase I regulatory region DNA binding +
                                                                is-aRNA polymerase II regulatory region DNA binding +
                                                                is-aRNA polymerase III regulatory region DNA binding +
                                                                is-aserum response element binding
                                                                is-asterol response element binding
                                                                is-atranscription regulatory region sequence-specific DNA binding +
                                                                is-atranscription termination site DNA binding +
                                                                is-avitamin D response element binding


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory