| GO term: | cytolytic granule |
| GO id: | GO:0044194 |
| Definition: | A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells. |
| Number of paths to term: | 14 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
cellular_componentcellcell partintracellularintracellular partcytoplasmcytoplasmic partvacuolelytic vacuolelysosomecytolytic granule [GO:0044194] (2 genes, 2 annotations)endolysosome +lysosomal glycocalyxlysosomal lumen +lysosomal membrane +lysosomal multienzyme complexmast cell granulemegasomeprimary lysosome +secondary lysosome +UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complexcellular_componentcellcell partintracellularintracellular partcytoplasmic partvacuolelytic vacuolelysosomecytolytic granule [GO:0044194] (2 genes, 2 annotations)endolysosome +lysosomal glycocalyxlysosomal lumen +lysosomal membrane +lysosomal multienzyme complexmast cell granulemegasomeprimary lysosome +secondary lysosome +UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complexcellular_componentcellcell partintracellularintracellular partintracellular organelleintracellular membrane-bounded organellevacuolelytic vacuolelysosomecytolytic granule [GO:0044194] (2 genes, 2 annotations)endolysosome +lysosomal glycocalyxlysosomal lumen +lysosomal membrane +lysosomal multienzyme complexmast cell granulemegasomeprimary lysosome +secondary lysosome +UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complexcellular_componentcellcell partintracellular partcytoplasmcytoplasmic partvacuolelytic vacuolelysosomecytolytic granule [GO:0044194] (2 genes, 2 annotations)endolysosome +lysosomal glycocalyxlysosomal lumen +lysosomal membrane +lysosomal multienzyme complexmast cell granulemegasomeprimary lysosome +secondary lysosome +UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complexcellular_componentcellcell partintracellular partcytoplasmic partvacuolelytic vacuolelysosomecytolytic granule [GO:0044194] (2 genes, 2 annotations)endolysosome +lysosomal glycocalyxlysosomal lumen +lysosomal membrane +lysosomal multienzyme complexmast cell granulemegasomeprimary lysosome +secondary lysosome +UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complexcellular_componentcellcell partintracellular partintracellular organelleintracellular membrane-bounded organellevacuolelytic vacuolelysosomecytolytic granule [GO:0044194] (2 genes, 2 annotations)endolysosome +lysosomal glycocalyxlysosomal lumen +lysosomal membrane +lysosomal multienzyme complexmast cell granulemegasomeprimary lysosome +secondary lysosome +UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complexcellular_componentcell partintracellularintracellular partcytoplasmcytoplasmic partvacuolelytic vacuolelysosomecytolytic granule [GO:0044194] (2 genes, 2 annotations)endolysosome +lysosomal glycocalyxlysosomal lumen +lysosomal membrane +lysosomal multienzyme complexmast cell granulemegasomeprimary lysosome +secondary lysosome +UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complexcellular_componentcell partintracellularintracellular partcytoplasmic partvacuolelytic vacuolelysosomecytolytic granule [GO:0044194] (2 genes, 2 annotations)endolysosome +lysosomal glycocalyxlysosomal lumen +lysosomal membrane +lysosomal multienzyme complexmast cell granulemegasomeprimary lysosome +secondary lysosome +UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complexcellular_componentcell partintracellularintracellular partintracellular organelleintracellular membrane-bounded organellevacuolelytic vacuolelysosomecytolytic granule [GO:0044194] (2 genes, 2 annotations)endolysosome +lysosomal glycocalyxlysosomal lumen +lysosomal membrane +lysosomal multienzyme complexmast cell granulemegasomeprimary lysosome +secondary lysosome +UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complexcellular_componentcell partintracellular partcytoplasmcytoplasmic partvacuolelytic vacuolelysosomecytolytic granule [GO:0044194] (2 genes, 2 annotations)endolysosome +lysosomal glycocalyxlysosomal lumen +lysosomal membrane +lysosomal multienzyme complexmast cell granulemegasomeprimary lysosome +secondary lysosome +UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complexcellular_componentcell partintracellular partcytoplasmic partvacuolelytic vacuolelysosomecytolytic granule [GO:0044194] (2 genes, 2 annotations)endolysosome +lysosomal glycocalyxlysosomal lumen +lysosomal membrane +lysosomal multienzyme complexmast cell granulemegasomeprimary lysosome +secondary lysosome +UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complexcellular_componentcell partintracellular partintracellular organelleintracellular membrane-bounded organellevacuolelytic vacuolelysosomecytolytic granule [GO:0044194] (2 genes, 2 annotations)endolysosome +lysosomal glycocalyxlysosomal lumen +lysosomal membrane +lysosomal multienzyme complexmast cell granulemegasomeprimary lysosome +secondary lysosome +UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complexcellular_componentorganelleintracellular organelleintracellular membrane-bounded organellevacuolelytic vacuolelysosomecytolytic granule [GO:0044194] (2 genes, 2 annotations)endolysosome +lysosomal glycocalyxlysosomal lumen +lysosomal membrane +lysosomal multienzyme complexmast cell granulemegasomeprimary lysosome +secondary lysosome +UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complexcellular_componentorganellemembrane-bounded organelleintracellular membrane-bounded organellevacuolelytic vacuolelysosomecytolytic granule [GO:0044194] (2 genes, 2 annotations)endolysosome +lysosomal glycocalyxlysosomal lumen +lysosomal membrane +lysosomal multienzyme complexmast cell granulemegasomeprimary lysosome +secondary lysosome +UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complexMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
||
|
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support. |
last database update 05/08/2013 MGI 5.13 |
|
|
|
||
Analysis Tools