| GO term: | beta selection |
| GO id: | GO:0043366 |
| Definition: | The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell. |
| Number of paths to term: | 46 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationT cell activationalpha-beta T cell activationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationT cell activationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationT cell activationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processcellular processsingle-organism cellular processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processcellular processsingle-organism cellular processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processdevelopmental processanatomical structure developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processdevelopmental processanatomical structure developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processdevelopmental processanatomical structure developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processdevelopmental processanatomical structure developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processdevelopmental processanatomical structure developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processdevelopmental processanatomical structure developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processdevelopmental processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processdevelopmental processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processdevelopmental processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processdevelopmental processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processdevelopmental processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processdevelopmental processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processdevelopmental processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processdevelopmental processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processimmune system processimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processimmune system processimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processimmune system processleukocyte activationlymphocyte activationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processimmune system processleukocyte activationlymphocyte activationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processimmune system processleukocyte activationlymphocyte activationT cell activationalpha-beta T cell activationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processimmune system processleukocyte activationlymphocyte activationT cell activationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processimmune system processleukocyte activationlymphocyte activationT cell activationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processimmune system processT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationT cell activationalpha-beta T cell activationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationT cell activationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationT cell activationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processsingle-organism processsingle-organism cellular processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processsingle-organism processsingle-organism cellular processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +biological_processsingle-organism processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitmentbeta selection [GO:0043366] (2 genes, 2 annotations)CD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processsingle-organism processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationT cell selectionbeta selection [GO:0043366] (2 genes, 2 annotations)extrathymic T cell selection +negative T cell selection +positive T cell selection +thymic T cell selection +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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