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Gene Ontology Browser
Term Detail
GO term:ubiquitin-ubiquitin ligase activity
Synonym: E4
GO id:GO:0034450
Definition:Catalysis of the reaction: ATP + ubiquitin + protein N-ubiquityl(n)lysine = AMP + diphosphate + protein N-ubiquityl(n+1)lysine. This reaction is the ligation of ubiquitin groups, via isopeptide bonds, to extend the length of the multiubiquitin chain attached to a substrate protein.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship

                is-acatalytic activity
                        is-atransferase activity
                                is-aubiquitin-protein transferase activity
                                        is-amitotic anaphase-promoting complex activity
                                        is-aubiquitin conjugating enzyme activity
                                        is-aubiquitin protein ligase activity
                                        is-aubiquitin-calmodulin ligase activity
                                        is-aubiquitin-ubiquitin ligase activity [GO:0034450] (8 genes, 8 annotations)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.19
The Jackson Laboratory