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Gene Ontology Browser
Term Detail
GO term:leptin-mediated signaling pathway
Synonym: adipocytokine signaling pathway
Synonym: leptin-mediated signalling pathway
GO id:GO:0033210
Definition:A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
Number of paths to term: 23

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-acytokine-mediated signaling pathway
                                                                is-aadiponectin-activated signaling pathway
                                                                is-achemokine-mediated signaling pathway +
                                                                is-aciliary neurotrophic factor-mediated signaling pathway
                                                                is-aerythropoietin-mediated signaling pathway
                                                                is-agranulocyte colony-stimulating factor signaling pathway
                                                                is-agranulocyte-macrophage colony-stimulating factor signaling pathway
                                                                is-ainterferon-gamma-mediated signaling pathway +
                                                                is-ainterleukin-1-mediated signaling pathway +
                                                                is-ainterleukin-11-mediated signaling pathway
                                                                is-ainterleukin-12-mediated signaling pathway
                                                                is-ainterleukin-13-mediated signaling pathway
                                                                is-ainterleukin-15-mediated signaling pathway
                                                                is-ainterleukin-17-mediated signaling pathway
                                                                is-ainterleukin-17A-mediated signaling pathway
                                                                is-ainterleukin-18-mediated signaling pathway +
                                                                is-ainterleukin-2-mediated signaling pathway +
                                                                is-ainterleukin-21-mediated signaling pathway
                                                                is-ainterleukin-23-mediated signaling pathway
                                                                is-ainterleukin-27-mediated signaling pathway +
                                                                is-ainterleukin-3-mediated signaling pathway
                                                                is-ainterleukin-32-mediated signaling pathway
                                                                is-ainterleukin-33-mediated signaling pathway
                                                                is-ainterleukin-34-mediated signaling pathway
                                                                is-ainterleukin-35-mediated signaling pathway +
                                                                is-ainterleukin-4-mediated signaling pathway +
                                                                is-ainterleukin-5-mediated signaling pathway
                                                                is-ainterleukin-6-mediated signaling pathway +
                                                                is-ainterleukin-7-mediated signaling pathway
                                                                is-ainterleukin-8-mediated signaling pathway
                                                                is-ainterleukin-9-mediated signaling pathway
                                                                is-aKit signaling pathway +
                                                                is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                        is-anegative regulation of appetite by leptin-mediated signaling pathway
                                                                is-amacrophage colony-stimulating factor signaling pathway +
                                                                is-amacrophage migration inhibitory factor signaling pathway +
                                                                negatively-regulatesnegative regulation of cytokine-mediated signaling pathway +
                                                                is-aoncostatin-M-mediated signaling pathway
                                                                positively-regulatespositive regulation of cytokine-mediated signaling pathway +
                                                                is-aprolactin signaling pathway +
                                                                regulatesregulation of cytokine-mediated signaling pathway +
                                                                is-atumor necrosis factor-mediated signaling pathway +
                                                                is-atype I interferon signaling pathway +
                                                                is-atype III interferon signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to cytokine stimulus
                                                        is-acytokine-mediated signaling pathway
                                                                is-aadiponectin-activated signaling pathway
                                                                is-achemokine-mediated signaling pathway +
                                                                is-aciliary neurotrophic factor-mediated signaling pathway
                                                                is-aerythropoietin-mediated signaling pathway
                                                                is-agranulocyte colony-stimulating factor signaling pathway
                                                                is-agranulocyte-macrophage colony-stimulating factor signaling pathway
                                                                is-ainterferon-gamma-mediated signaling pathway +
                                                                is-ainterleukin-1-mediated signaling pathway +
                                                                is-ainterleukin-11-mediated signaling pathway
                                                                is-ainterleukin-12-mediated signaling pathway
                                                                is-ainterleukin-13-mediated signaling pathway
                                                                is-ainterleukin-15-mediated signaling pathway
                                                                is-ainterleukin-17-mediated signaling pathway
                                                                is-ainterleukin-17A-mediated signaling pathway
                                                                is-ainterleukin-18-mediated signaling pathway +
                                                                is-ainterleukin-2-mediated signaling pathway +
                                                                is-ainterleukin-21-mediated signaling pathway
                                                                is-ainterleukin-23-mediated signaling pathway
                                                                is-ainterleukin-27-mediated signaling pathway +
                                                                is-ainterleukin-3-mediated signaling pathway
                                                                is-ainterleukin-32-mediated signaling pathway
                                                                is-ainterleukin-33-mediated signaling pathway
                                                                is-ainterleukin-34-mediated signaling pathway
                                                                is-ainterleukin-35-mediated signaling pathway +
                                                                is-ainterleukin-4-mediated signaling pathway +
                                                                is-ainterleukin-5-mediated signaling pathway
                                                                is-ainterleukin-6-mediated signaling pathway +
                                                                is-ainterleukin-7-mediated signaling pathway
                                                                is-ainterleukin-8-mediated signaling pathway
                                                                is-ainterleukin-9-mediated signaling pathway
                                                                is-aKit signaling pathway +
                                                                is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                        is-anegative regulation of appetite by leptin-mediated signaling pathway
                                                                is-amacrophage colony-stimulating factor signaling pathway +
                                                                is-amacrophage migration inhibitory factor signaling pathway +
                                                                negatively-regulatesnegative regulation of cytokine-mediated signaling pathway +
                                                                is-aoncostatin-M-mediated signaling pathway
                                                                positively-regulatespositive regulation of cytokine-mediated signaling pathway +
                                                                is-aprolactin signaling pathway +
                                                                regulatesregulation of cytokine-mediated signaling pathway +
                                                                is-atumor necrosis factor-mediated signaling pathway +
                                                                is-atype I interferon signaling pathway +
                                                                is-atype III interferon signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to hormone stimulus
                                                        is-acellular response to leptin stimulus
                                                                is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                        is-anegative regulation of appetite by leptin-mediated signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-acytokine-mediated signaling pathway
                                                        is-aadiponectin-activated signaling pathway
                                                        is-achemokine-mediated signaling pathway +
                                                        is-aciliary neurotrophic factor-mediated signaling pathway
                                                        is-aerythropoietin-mediated signaling pathway
                                                        is-agranulocyte colony-stimulating factor signaling pathway
                                                        is-agranulocyte-macrophage colony-stimulating factor signaling pathway
                                                        is-ainterferon-gamma-mediated signaling pathway +
                                                        is-ainterleukin-1-mediated signaling pathway +
                                                        is-ainterleukin-11-mediated signaling pathway
                                                        is-ainterleukin-12-mediated signaling pathway
                                                        is-ainterleukin-13-mediated signaling pathway
                                                        is-ainterleukin-15-mediated signaling pathway
                                                        is-ainterleukin-17-mediated signaling pathway
                                                        is-ainterleukin-17A-mediated signaling pathway
                                                        is-ainterleukin-18-mediated signaling pathway +
                                                        is-ainterleukin-2-mediated signaling pathway +
                                                        is-ainterleukin-21-mediated signaling pathway
                                                        is-ainterleukin-23-mediated signaling pathway
                                                        is-ainterleukin-27-mediated signaling pathway +
                                                        is-ainterleukin-3-mediated signaling pathway
                                                        is-ainterleukin-32-mediated signaling pathway
                                                        is-ainterleukin-33-mediated signaling pathway
                                                        is-ainterleukin-34-mediated signaling pathway
                                                        is-ainterleukin-35-mediated signaling pathway +
                                                        is-ainterleukin-4-mediated signaling pathway +
                                                        is-ainterleukin-5-mediated signaling pathway
                                                        is-ainterleukin-6-mediated signaling pathway +
                                                        is-ainterleukin-7-mediated signaling pathway
                                                        is-ainterleukin-8-mediated signaling pathway
                                                        is-ainterleukin-9-mediated signaling pathway
                                                        is-aKit signaling pathway +
                                                        is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                is-anegative regulation of appetite by leptin-mediated signaling pathway
                                                        is-amacrophage colony-stimulating factor signaling pathway +
                                                        is-amacrophage migration inhibitory factor signaling pathway +
                                                        negatively-regulatesnegative regulation of cytokine-mediated signaling pathway +
                                                        is-aoncostatin-M-mediated signaling pathway
                                                        positively-regulatespositive regulation of cytokine-mediated signaling pathway +
                                                        is-aprolactin signaling pathway +
                                                        regulatesregulation of cytokine-mediated signaling pathway +
                                                        is-atumor necrosis factor-mediated signaling pathway +
                                                        is-atype I interferon signaling pathway +
                                                        is-atype III interferon signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-acytokine-mediated signaling pathway
                                                        is-aadiponectin-activated signaling pathway
                                                        is-achemokine-mediated signaling pathway +
                                                        is-aciliary neurotrophic factor-mediated signaling pathway
                                                        is-aerythropoietin-mediated signaling pathway
                                                        is-agranulocyte colony-stimulating factor signaling pathway
                                                        is-agranulocyte-macrophage colony-stimulating factor signaling pathway
                                                        is-ainterferon-gamma-mediated signaling pathway +
                                                        is-ainterleukin-1-mediated signaling pathway +
                                                        is-ainterleukin-11-mediated signaling pathway
                                                        is-ainterleukin-12-mediated signaling pathway
                                                        is-ainterleukin-13-mediated signaling pathway
                                                        is-ainterleukin-15-mediated signaling pathway
                                                        is-ainterleukin-17-mediated signaling pathway
                                                        is-ainterleukin-17A-mediated signaling pathway
                                                        is-ainterleukin-18-mediated signaling pathway +
                                                        is-ainterleukin-2-mediated signaling pathway +
                                                        is-ainterleukin-21-mediated signaling pathway
                                                        is-ainterleukin-23-mediated signaling pathway
                                                        is-ainterleukin-27-mediated signaling pathway +
                                                        is-ainterleukin-3-mediated signaling pathway
                                                        is-ainterleukin-32-mediated signaling pathway
                                                        is-ainterleukin-33-mediated signaling pathway
                                                        is-ainterleukin-34-mediated signaling pathway
                                                        is-ainterleukin-35-mediated signaling pathway +
                                                        is-ainterleukin-4-mediated signaling pathway +
                                                        is-ainterleukin-5-mediated signaling pathway
                                                        is-ainterleukin-6-mediated signaling pathway +
                                                        is-ainterleukin-7-mediated signaling pathway
                                                        is-ainterleukin-8-mediated signaling pathway
                                                        is-ainterleukin-9-mediated signaling pathway
                                                        is-aKit signaling pathway +
                                                        is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                is-anegative regulation of appetite by leptin-mediated signaling pathway
                                                        is-amacrophage colony-stimulating factor signaling pathway +
                                                        is-amacrophage migration inhibitory factor signaling pathway +
                                                        negatively-regulatesnegative regulation of cytokine-mediated signaling pathway +
                                                        is-aoncostatin-M-mediated signaling pathway
                                                        positively-regulatespositive regulation of cytokine-mediated signaling pathway +
                                                        is-aprolactin signaling pathway +
                                                        regulatesregulation of cytokine-mediated signaling pathway +
                                                        is-atumor necrosis factor-mediated signaling pathway +
                                                        is-atype I interferon signaling pathway +
                                                        is-atype III interferon signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-acytokine-mediated signaling pathway
                                                                is-aadiponectin-activated signaling pathway
                                                                is-achemokine-mediated signaling pathway +
                                                                is-aciliary neurotrophic factor-mediated signaling pathway
                                                                is-aerythropoietin-mediated signaling pathway
                                                                is-agranulocyte colony-stimulating factor signaling pathway
                                                                is-agranulocyte-macrophage colony-stimulating factor signaling pathway
                                                                is-ainterferon-gamma-mediated signaling pathway +
                                                                is-ainterleukin-1-mediated signaling pathway +
                                                                is-ainterleukin-11-mediated signaling pathway
                                                                is-ainterleukin-12-mediated signaling pathway
                                                                is-ainterleukin-13-mediated signaling pathway
                                                                is-ainterleukin-15-mediated signaling pathway
                                                                is-ainterleukin-17-mediated signaling pathway
                                                                is-ainterleukin-17A-mediated signaling pathway
                                                                is-ainterleukin-18-mediated signaling pathway +
                                                                is-ainterleukin-2-mediated signaling pathway +
                                                                is-ainterleukin-21-mediated signaling pathway
                                                                is-ainterleukin-23-mediated signaling pathway
                                                                is-ainterleukin-27-mediated signaling pathway +
                                                                is-ainterleukin-3-mediated signaling pathway
                                                                is-ainterleukin-32-mediated signaling pathway
                                                                is-ainterleukin-33-mediated signaling pathway
                                                                is-ainterleukin-34-mediated signaling pathway
                                                                is-ainterleukin-35-mediated signaling pathway +
                                                                is-ainterleukin-4-mediated signaling pathway +
                                                                is-ainterleukin-5-mediated signaling pathway
                                                                is-ainterleukin-6-mediated signaling pathway +
                                                                is-ainterleukin-7-mediated signaling pathway
                                                                is-ainterleukin-8-mediated signaling pathway
                                                                is-ainterleukin-9-mediated signaling pathway
                                                                is-aKit signaling pathway +
                                                                is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                        is-anegative regulation of appetite by leptin-mediated signaling pathway
                                                                is-amacrophage colony-stimulating factor signaling pathway +
                                                                is-amacrophage migration inhibitory factor signaling pathway +
                                                                negatively-regulatesnegative regulation of cytokine-mediated signaling pathway +
                                                                is-aoncostatin-M-mediated signaling pathway
                                                                positively-regulatespositive regulation of cytokine-mediated signaling pathway +
                                                                is-aprolactin signaling pathway +
                                                                regulatesregulation of cytokine-mediated signaling pathway +
                                                                is-atumor necrosis factor-mediated signaling pathway +
                                                                is-atype I interferon signaling pathway +
                                                                is-atype III interferon signaling pathway


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-acytokine-mediated signaling pathway
                                                        is-aadiponectin-activated signaling pathway
                                                        is-achemokine-mediated signaling pathway +
                                                        is-aciliary neurotrophic factor-mediated signaling pathway
                                                        is-aerythropoietin-mediated signaling pathway
                                                        is-agranulocyte colony-stimulating factor signaling pathway
                                                        is-agranulocyte-macrophage colony-stimulating factor signaling pathway
                                                        is-ainterferon-gamma-mediated signaling pathway +
                                                        is-ainterleukin-1-mediated signaling pathway +
                                                        is-ainterleukin-11-mediated signaling pathway
                                                        is-ainterleukin-12-mediated signaling pathway
                                                        is-ainterleukin-13-mediated signaling pathway
                                                        is-ainterleukin-15-mediated signaling pathway
                                                        is-ainterleukin-17-mediated signaling pathway
                                                        is-ainterleukin-17A-mediated signaling pathway
                                                        is-ainterleukin-18-mediated signaling pathway +
                                                        is-ainterleukin-2-mediated signaling pathway +
                                                        is-ainterleukin-21-mediated signaling pathway
                                                        is-ainterleukin-23-mediated signaling pathway
                                                        is-ainterleukin-27-mediated signaling pathway +
                                                        is-ainterleukin-3-mediated signaling pathway
                                                        is-ainterleukin-32-mediated signaling pathway
                                                        is-ainterleukin-33-mediated signaling pathway
                                                        is-ainterleukin-34-mediated signaling pathway
                                                        is-ainterleukin-35-mediated signaling pathway +
                                                        is-ainterleukin-4-mediated signaling pathway +
                                                        is-ainterleukin-5-mediated signaling pathway
                                                        is-ainterleukin-6-mediated signaling pathway +
                                                        is-ainterleukin-7-mediated signaling pathway
                                                        is-ainterleukin-8-mediated signaling pathway
                                                        is-ainterleukin-9-mediated signaling pathway
                                                        is-aKit signaling pathway +
                                                        is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                is-anegative regulation of appetite by leptin-mediated signaling pathway
                                                        is-amacrophage colony-stimulating factor signaling pathway +
                                                        is-amacrophage migration inhibitory factor signaling pathway +
                                                        negatively-regulatesnegative regulation of cytokine-mediated signaling pathway +
                                                        is-aoncostatin-M-mediated signaling pathway
                                                        positively-regulatespositive regulation of cytokine-mediated signaling pathway +
                                                        is-aprolactin signaling pathway +
                                                        regulatesregulation of cytokine-mediated signaling pathway +
                                                        is-atumor necrosis factor-mediated signaling pathway +
                                                        is-atype I interferon signaling pathway +
                                                        is-atype III interferon signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to cytokine stimulus
                                                        is-acytokine-mediated signaling pathway
                                                                is-aadiponectin-activated signaling pathway
                                                                is-achemokine-mediated signaling pathway +
                                                                is-aciliary neurotrophic factor-mediated signaling pathway
                                                                is-aerythropoietin-mediated signaling pathway
                                                                is-agranulocyte colony-stimulating factor signaling pathway
                                                                is-agranulocyte-macrophage colony-stimulating factor signaling pathway
                                                                is-ainterferon-gamma-mediated signaling pathway +
                                                                is-ainterleukin-1-mediated signaling pathway +
                                                                is-ainterleukin-11-mediated signaling pathway
                                                                is-ainterleukin-12-mediated signaling pathway
                                                                is-ainterleukin-13-mediated signaling pathway
                                                                is-ainterleukin-15-mediated signaling pathway
                                                                is-ainterleukin-17-mediated signaling pathway
                                                                is-ainterleukin-17A-mediated signaling pathway
                                                                is-ainterleukin-18-mediated signaling pathway +
                                                                is-ainterleukin-2-mediated signaling pathway +
                                                                is-ainterleukin-21-mediated signaling pathway
                                                                is-ainterleukin-23-mediated signaling pathway
                                                                is-ainterleukin-27-mediated signaling pathway +
                                                                is-ainterleukin-3-mediated signaling pathway
                                                                is-ainterleukin-32-mediated signaling pathway
                                                                is-ainterleukin-33-mediated signaling pathway
                                                                is-ainterleukin-34-mediated signaling pathway
                                                                is-ainterleukin-35-mediated signaling pathway +
                                                                is-ainterleukin-4-mediated signaling pathway +
                                                                is-ainterleukin-5-mediated signaling pathway
                                                                is-ainterleukin-6-mediated signaling pathway +
                                                                is-ainterleukin-7-mediated signaling pathway
                                                                is-ainterleukin-8-mediated signaling pathway
                                                                is-ainterleukin-9-mediated signaling pathway
                                                                is-aKit signaling pathway +
                                                                is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                        is-anegative regulation of appetite by leptin-mediated signaling pathway
                                                                is-amacrophage colony-stimulating factor signaling pathway +
                                                                is-amacrophage migration inhibitory factor signaling pathway +
                                                                negatively-regulatesnegative regulation of cytokine-mediated signaling pathway +
                                                                is-aoncostatin-M-mediated signaling pathway
                                                                positively-regulatespositive regulation of cytokine-mediated signaling pathway +
                                                                is-aprolactin signaling pathway +
                                                                regulatesregulation of cytokine-mediated signaling pathway +
                                                                is-atumor necrosis factor-mediated signaling pathway +
                                                                is-atype I interferon signaling pathway +
                                                                is-atype III interferon signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to hormone stimulus
                                                        is-acellular response to leptin stimulus
                                                                is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                        is-anegative regulation of appetite by leptin-mediated signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-acytokine-mediated signaling pathway
                                                        is-aadiponectin-activated signaling pathway
                                                        is-achemokine-mediated signaling pathway +
                                                        is-aciliary neurotrophic factor-mediated signaling pathway
                                                        is-aerythropoietin-mediated signaling pathway
                                                        is-agranulocyte colony-stimulating factor signaling pathway
                                                        is-agranulocyte-macrophage colony-stimulating factor signaling pathway
                                                        is-ainterferon-gamma-mediated signaling pathway +
                                                        is-ainterleukin-1-mediated signaling pathway +
                                                        is-ainterleukin-11-mediated signaling pathway
                                                        is-ainterleukin-12-mediated signaling pathway
                                                        is-ainterleukin-13-mediated signaling pathway
                                                        is-ainterleukin-15-mediated signaling pathway
                                                        is-ainterleukin-17-mediated signaling pathway
                                                        is-ainterleukin-17A-mediated signaling pathway
                                                        is-ainterleukin-18-mediated signaling pathway +
                                                        is-ainterleukin-2-mediated signaling pathway +
                                                        is-ainterleukin-21-mediated signaling pathway
                                                        is-ainterleukin-23-mediated signaling pathway
                                                        is-ainterleukin-27-mediated signaling pathway +
                                                        is-ainterleukin-3-mediated signaling pathway
                                                        is-ainterleukin-32-mediated signaling pathway
                                                        is-ainterleukin-33-mediated signaling pathway
                                                        is-ainterleukin-34-mediated signaling pathway
                                                        is-ainterleukin-35-mediated signaling pathway +
                                                        is-ainterleukin-4-mediated signaling pathway +
                                                        is-ainterleukin-5-mediated signaling pathway
                                                        is-ainterleukin-6-mediated signaling pathway +
                                                        is-ainterleukin-7-mediated signaling pathway
                                                        is-ainterleukin-8-mediated signaling pathway
                                                        is-ainterleukin-9-mediated signaling pathway
                                                        is-aKit signaling pathway +
                                                        is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                is-anegative regulation of appetite by leptin-mediated signaling pathway
                                                        is-amacrophage colony-stimulating factor signaling pathway +
                                                        is-amacrophage migration inhibitory factor signaling pathway +
                                                        negatively-regulatesnegative regulation of cytokine-mediated signaling pathway +
                                                        is-aoncostatin-M-mediated signaling pathway
                                                        positively-regulatespositive regulation of cytokine-mediated signaling pathway +
                                                        is-aprolactin signaling pathway +
                                                        regulatesregulation of cytokine-mediated signaling pathway +
                                                        is-atumor necrosis factor-mediated signaling pathway +
                                                        is-atype I interferon signaling pathway +
                                                        is-atype III interferon signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to cytokine stimulus
                                                        is-acytokine-mediated signaling pathway
                                                                is-aadiponectin-activated signaling pathway
                                                                is-achemokine-mediated signaling pathway +
                                                                is-aciliary neurotrophic factor-mediated signaling pathway
                                                                is-aerythropoietin-mediated signaling pathway
                                                                is-agranulocyte colony-stimulating factor signaling pathway
                                                                is-agranulocyte-macrophage colony-stimulating factor signaling pathway
                                                                is-ainterferon-gamma-mediated signaling pathway +
                                                                is-ainterleukin-1-mediated signaling pathway +
                                                                is-ainterleukin-11-mediated signaling pathway
                                                                is-ainterleukin-12-mediated signaling pathway
                                                                is-ainterleukin-13-mediated signaling pathway
                                                                is-ainterleukin-15-mediated signaling pathway
                                                                is-ainterleukin-17-mediated signaling pathway
                                                                is-ainterleukin-17A-mediated signaling pathway
                                                                is-ainterleukin-18-mediated signaling pathway +
                                                                is-ainterleukin-2-mediated signaling pathway +
                                                                is-ainterleukin-21-mediated signaling pathway
                                                                is-ainterleukin-23-mediated signaling pathway
                                                                is-ainterleukin-27-mediated signaling pathway +
                                                                is-ainterleukin-3-mediated signaling pathway
                                                                is-ainterleukin-32-mediated signaling pathway
                                                                is-ainterleukin-33-mediated signaling pathway
                                                                is-ainterleukin-34-mediated signaling pathway
                                                                is-ainterleukin-35-mediated signaling pathway +
                                                                is-ainterleukin-4-mediated signaling pathway +
                                                                is-ainterleukin-5-mediated signaling pathway
                                                                is-ainterleukin-6-mediated signaling pathway +
                                                                is-ainterleukin-7-mediated signaling pathway
                                                                is-ainterleukin-8-mediated signaling pathway
                                                                is-ainterleukin-9-mediated signaling pathway
                                                                is-aKit signaling pathway +
                                                                is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                        is-anegative regulation of appetite by leptin-mediated signaling pathway
                                                                is-amacrophage colony-stimulating factor signaling pathway +
                                                                is-amacrophage migration inhibitory factor signaling pathway +
                                                                negatively-regulatesnegative regulation of cytokine-mediated signaling pathway +
                                                                is-aoncostatin-M-mediated signaling pathway
                                                                positively-regulatespositive regulation of cytokine-mediated signaling pathway +
                                                                is-aprolactin signaling pathway +
                                                                regulatesregulation of cytokine-mediated signaling pathway +
                                                                is-atumor necrosis factor-mediated signaling pathway +
                                                                is-atype I interferon signaling pathway +
                                                                is-atype III interferon signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to hormone stimulus
                                                        is-acellular response to leptin stimulus
                                                                is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                        is-anegative regulation of appetite by leptin-mediated signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-aresponse to organic substance
                                        is-acellular response to organic substance
                                                is-acellular response to cytokine stimulus
                                                        is-acytokine-mediated signaling pathway
                                                                is-aadiponectin-activated signaling pathway
                                                                is-achemokine-mediated signaling pathway +
                                                                is-aciliary neurotrophic factor-mediated signaling pathway
                                                                is-aerythropoietin-mediated signaling pathway
                                                                is-agranulocyte colony-stimulating factor signaling pathway
                                                                is-agranulocyte-macrophage colony-stimulating factor signaling pathway
                                                                is-ainterferon-gamma-mediated signaling pathway +
                                                                is-ainterleukin-1-mediated signaling pathway +
                                                                is-ainterleukin-11-mediated signaling pathway
                                                                is-ainterleukin-12-mediated signaling pathway
                                                                is-ainterleukin-13-mediated signaling pathway
                                                                is-ainterleukin-15-mediated signaling pathway
                                                                is-ainterleukin-17-mediated signaling pathway
                                                                is-ainterleukin-17A-mediated signaling pathway
                                                                is-ainterleukin-18-mediated signaling pathway +
                                                                is-ainterleukin-2-mediated signaling pathway +
                                                                is-ainterleukin-21-mediated signaling pathway
                                                                is-ainterleukin-23-mediated signaling pathway
                                                                is-ainterleukin-27-mediated signaling pathway +
                                                                is-ainterleukin-3-mediated signaling pathway
                                                                is-ainterleukin-32-mediated signaling pathway
                                                                is-ainterleukin-33-mediated signaling pathway
                                                                is-ainterleukin-34-mediated signaling pathway
                                                                is-ainterleukin-35-mediated signaling pathway +
                                                                is-ainterleukin-4-mediated signaling pathway +
                                                                is-ainterleukin-5-mediated signaling pathway
                                                                is-ainterleukin-6-mediated signaling pathway +
                                                                is-ainterleukin-7-mediated signaling pathway
                                                                is-ainterleukin-8-mediated signaling pathway
                                                                is-ainterleukin-9-mediated signaling pathway
                                                                is-aKit signaling pathway +
                                                                is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                        is-anegative regulation of appetite by leptin-mediated signaling pathway
                                                                is-amacrophage colony-stimulating factor signaling pathway +
                                                                is-amacrophage migration inhibitory factor signaling pathway +
                                                                negatively-regulatesnegative regulation of cytokine-mediated signaling pathway +
                                                                is-aoncostatin-M-mediated signaling pathway
                                                                positively-regulatespositive regulation of cytokine-mediated signaling pathway +
                                                                is-aprolactin signaling pathway +
                                                                regulatesregulation of cytokine-mediated signaling pathway +
                                                                is-atumor necrosis factor-mediated signaling pathway +
                                                                is-atype I interferon signaling pathway +
                                                                is-atype III interferon signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-aresponse to organic substance
                                        is-acellular response to organic substance
                                                is-acellular response to hormone stimulus
                                                        is-acellular response to leptin stimulus
                                                                is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                        is-anegative regulation of appetite by leptin-mediated signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-aresponse to organic substance
                                        is-aresponse to cytokine
                                                is-acellular response to cytokine stimulus
                                                        is-acytokine-mediated signaling pathway
                                                                is-aadiponectin-activated signaling pathway
                                                                is-achemokine-mediated signaling pathway +
                                                                is-aciliary neurotrophic factor-mediated signaling pathway
                                                                is-aerythropoietin-mediated signaling pathway
                                                                is-agranulocyte colony-stimulating factor signaling pathway
                                                                is-agranulocyte-macrophage colony-stimulating factor signaling pathway
                                                                is-ainterferon-gamma-mediated signaling pathway +
                                                                is-ainterleukin-1-mediated signaling pathway +
                                                                is-ainterleukin-11-mediated signaling pathway
                                                                is-ainterleukin-12-mediated signaling pathway
                                                                is-ainterleukin-13-mediated signaling pathway
                                                                is-ainterleukin-15-mediated signaling pathway
                                                                is-ainterleukin-17-mediated signaling pathway
                                                                is-ainterleukin-17A-mediated signaling pathway
                                                                is-ainterleukin-18-mediated signaling pathway +
                                                                is-ainterleukin-2-mediated signaling pathway +
                                                                is-ainterleukin-21-mediated signaling pathway
                                                                is-ainterleukin-23-mediated signaling pathway
                                                                is-ainterleukin-27-mediated signaling pathway +
                                                                is-ainterleukin-3-mediated signaling pathway
                                                                is-ainterleukin-32-mediated signaling pathway
                                                                is-ainterleukin-33-mediated signaling pathway
                                                                is-ainterleukin-34-mediated signaling pathway
                                                                is-ainterleukin-35-mediated signaling pathway +
                                                                is-ainterleukin-4-mediated signaling pathway +
                                                                is-ainterleukin-5-mediated signaling pathway
                                                                is-ainterleukin-6-mediated signaling pathway +
                                                                is-ainterleukin-7-mediated signaling pathway
                                                                is-ainterleukin-8-mediated signaling pathway
                                                                is-ainterleukin-9-mediated signaling pathway
                                                                is-aKit signaling pathway +
                                                                is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                        is-anegative regulation of appetite by leptin-mediated signaling pathway
                                                                is-amacrophage colony-stimulating factor signaling pathway +
                                                                is-amacrophage migration inhibitory factor signaling pathway +
                                                                negatively-regulatesnegative regulation of cytokine-mediated signaling pathway +
                                                                is-aoncostatin-M-mediated signaling pathway
                                                                positively-regulatespositive regulation of cytokine-mediated signaling pathway +
                                                                is-aprolactin signaling pathway +
                                                                regulatesregulation of cytokine-mediated signaling pathway +
                                                                is-atumor necrosis factor-mediated signaling pathway +
                                                                is-atype I interferon signaling pathway +
                                                                is-atype III interferon signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-aresponse to organic substance
                                        is-aresponse to hormone
                                                is-acellular response to hormone stimulus
                                                        is-acellular response to leptin stimulus
                                                                is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                        is-anegative regulation of appetite by leptin-mediated signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-aresponse to organic substance
                                        is-aresponse to hormone
                                                is-aresponse to leptin
                                                        is-acellular response to leptin stimulus
                                                                is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                        is-anegative regulation of appetite by leptin-mediated signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to endogenous stimulus
                                is-acellular response to endogenous stimulus
                                        is-acellular response to hormone stimulus
                                                is-acellular response to leptin stimulus
                                                        is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                is-anegative regulation of appetite by leptin-mediated signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to endogenous stimulus
                                is-aresponse to hormone
                                        is-acellular response to hormone stimulus
                                                is-acellular response to leptin stimulus
                                                        is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                is-anegative regulation of appetite by leptin-mediated signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to endogenous stimulus
                                is-aresponse to hormone
                                        is-aresponse to leptin
                                                is-acellular response to leptin stimulus
                                                        is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                is-anegative regulation of appetite by leptin-mediated signaling pathway


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-acytokine-mediated signaling pathway
                                                        is-aadiponectin-activated signaling pathway
                                                        is-achemokine-mediated signaling pathway +
                                                        is-aciliary neurotrophic factor-mediated signaling pathway
                                                        is-aerythropoietin-mediated signaling pathway
                                                        is-agranulocyte colony-stimulating factor signaling pathway
                                                        is-agranulocyte-macrophage colony-stimulating factor signaling pathway
                                                        is-ainterferon-gamma-mediated signaling pathway +
                                                        is-ainterleukin-1-mediated signaling pathway +
                                                        is-ainterleukin-11-mediated signaling pathway
                                                        is-ainterleukin-12-mediated signaling pathway
                                                        is-ainterleukin-13-mediated signaling pathway
                                                        is-ainterleukin-15-mediated signaling pathway
                                                        is-ainterleukin-17-mediated signaling pathway
                                                        is-ainterleukin-17A-mediated signaling pathway
                                                        is-ainterleukin-18-mediated signaling pathway +
                                                        is-ainterleukin-2-mediated signaling pathway +
                                                        is-ainterleukin-21-mediated signaling pathway
                                                        is-ainterleukin-23-mediated signaling pathway
                                                        is-ainterleukin-27-mediated signaling pathway +
                                                        is-ainterleukin-3-mediated signaling pathway
                                                        is-ainterleukin-32-mediated signaling pathway
                                                        is-ainterleukin-33-mediated signaling pathway
                                                        is-ainterleukin-34-mediated signaling pathway
                                                        is-ainterleukin-35-mediated signaling pathway +
                                                        is-ainterleukin-4-mediated signaling pathway +
                                                        is-ainterleukin-5-mediated signaling pathway
                                                        is-ainterleukin-6-mediated signaling pathway +
                                                        is-ainterleukin-7-mediated signaling pathway
                                                        is-ainterleukin-8-mediated signaling pathway
                                                        is-ainterleukin-9-mediated signaling pathway
                                                        is-aKit signaling pathway +
                                                        is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                is-anegative regulation of appetite by leptin-mediated signaling pathway
                                                        is-amacrophage colony-stimulating factor signaling pathway +
                                                        is-amacrophage migration inhibitory factor signaling pathway +
                                                        negatively-regulatesnegative regulation of cytokine-mediated signaling pathway +
                                                        is-aoncostatin-M-mediated signaling pathway
                                                        positively-regulatespositive regulation of cytokine-mediated signaling pathway +
                                                        is-aprolactin signaling pathway +
                                                        regulatesregulation of cytokine-mediated signaling pathway +
                                                        is-atumor necrosis factor-mediated signaling pathway +
                                                        is-atype I interferon signaling pathway +
                                                        is-atype III interferon signaling pathway


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-acytokine-mediated signaling pathway
                                                        is-aadiponectin-activated signaling pathway
                                                        is-achemokine-mediated signaling pathway +
                                                        is-aciliary neurotrophic factor-mediated signaling pathway
                                                        is-aerythropoietin-mediated signaling pathway
                                                        is-agranulocyte colony-stimulating factor signaling pathway
                                                        is-agranulocyte-macrophage colony-stimulating factor signaling pathway
                                                        is-ainterferon-gamma-mediated signaling pathway +
                                                        is-ainterleukin-1-mediated signaling pathway +
                                                        is-ainterleukin-11-mediated signaling pathway
                                                        is-ainterleukin-12-mediated signaling pathway
                                                        is-ainterleukin-13-mediated signaling pathway
                                                        is-ainterleukin-15-mediated signaling pathway
                                                        is-ainterleukin-17-mediated signaling pathway
                                                        is-ainterleukin-17A-mediated signaling pathway
                                                        is-ainterleukin-18-mediated signaling pathway +
                                                        is-ainterleukin-2-mediated signaling pathway +
                                                        is-ainterleukin-21-mediated signaling pathway
                                                        is-ainterleukin-23-mediated signaling pathway
                                                        is-ainterleukin-27-mediated signaling pathway +
                                                        is-ainterleukin-3-mediated signaling pathway
                                                        is-ainterleukin-32-mediated signaling pathway
                                                        is-ainterleukin-33-mediated signaling pathway
                                                        is-ainterleukin-34-mediated signaling pathway
                                                        is-ainterleukin-35-mediated signaling pathway +
                                                        is-ainterleukin-4-mediated signaling pathway +
                                                        is-ainterleukin-5-mediated signaling pathway
                                                        is-ainterleukin-6-mediated signaling pathway +
                                                        is-ainterleukin-7-mediated signaling pathway
                                                        is-ainterleukin-8-mediated signaling pathway
                                                        is-ainterleukin-9-mediated signaling pathway
                                                        is-aKit signaling pathway +
                                                        is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                is-anegative regulation of appetite by leptin-mediated signaling pathway
                                                        is-amacrophage colony-stimulating factor signaling pathway +
                                                        is-amacrophage migration inhibitory factor signaling pathway +
                                                        negatively-regulatesnegative regulation of cytokine-mediated signaling pathway +
                                                        is-aoncostatin-M-mediated signaling pathway
                                                        positively-regulatespositive regulation of cytokine-mediated signaling pathway +
                                                        is-aprolactin signaling pathway +
                                                        regulatesregulation of cytokine-mediated signaling pathway +
                                                        is-atumor necrosis factor-mediated signaling pathway +
                                                        is-atype I interferon signaling pathway +
                                                        is-atype III interferon signaling pathway


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-acytokine-mediated signaling pathway
                                                                is-aadiponectin-activated signaling pathway
                                                                is-achemokine-mediated signaling pathway +
                                                                is-aciliary neurotrophic factor-mediated signaling pathway
                                                                is-aerythropoietin-mediated signaling pathway
                                                                is-agranulocyte colony-stimulating factor signaling pathway
                                                                is-agranulocyte-macrophage colony-stimulating factor signaling pathway
                                                                is-ainterferon-gamma-mediated signaling pathway +
                                                                is-ainterleukin-1-mediated signaling pathway +
                                                                is-ainterleukin-11-mediated signaling pathway
                                                                is-ainterleukin-12-mediated signaling pathway
                                                                is-ainterleukin-13-mediated signaling pathway
                                                                is-ainterleukin-15-mediated signaling pathway
                                                                is-ainterleukin-17-mediated signaling pathway
                                                                is-ainterleukin-17A-mediated signaling pathway
                                                                is-ainterleukin-18-mediated signaling pathway +
                                                                is-ainterleukin-2-mediated signaling pathway +
                                                                is-ainterleukin-21-mediated signaling pathway
                                                                is-ainterleukin-23-mediated signaling pathway
                                                                is-ainterleukin-27-mediated signaling pathway +
                                                                is-ainterleukin-3-mediated signaling pathway
                                                                is-ainterleukin-32-mediated signaling pathway
                                                                is-ainterleukin-33-mediated signaling pathway
                                                                is-ainterleukin-34-mediated signaling pathway
                                                                is-ainterleukin-35-mediated signaling pathway +
                                                                is-ainterleukin-4-mediated signaling pathway +
                                                                is-ainterleukin-5-mediated signaling pathway
                                                                is-ainterleukin-6-mediated signaling pathway +
                                                                is-ainterleukin-7-mediated signaling pathway
                                                                is-ainterleukin-8-mediated signaling pathway
                                                                is-ainterleukin-9-mediated signaling pathway
                                                                is-aKit signaling pathway +
                                                                is-aleptin-mediated signaling pathway [GO:0033210] (8 genes, 11 annotations)
                                                                        is-anegative regulation of appetite by leptin-mediated signaling pathway
                                                                is-amacrophage colony-stimulating factor signaling pathway +
                                                                is-amacrophage migration inhibitory factor signaling pathway +
                                                                negatively-regulatesnegative regulation of cytokine-mediated signaling pathway +
                                                                is-aoncostatin-M-mediated signaling pathway
                                                                positively-regulatespositive regulation of cytokine-mediated signaling pathway +
                                                                is-aprolactin signaling pathway +
                                                                regulatesregulation of cytokine-mediated signaling pathway +
                                                                is-atumor necrosis factor-mediated signaling pathway +
                                                                is-atype I interferon signaling pathway +
                                                                is-atype III interferon signaling pathway


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory