About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:negative regulation of synaptic plasticity
Synonym: down regulation of synaptic plasticity
Synonym: down-regulation of synaptic plasticity
Synonym: downregulation of synaptic plasticity
Synonym: inhibition of synaptic plasticity
GO id:GO:0031914
Definition:A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
Number of paths to term: 16

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-aregulation of cell communication
                                                is-aregulation of synaptic transmission
                                                        is-aregulation of synaptic plasticity
                                                                is-along term synaptic depression +
                                                                is-along-term synaptic potentiation +
                                                                is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                                        is-anegative regulation of synaptic metaplasticity
                                                                is-apositive regulation of synaptic plasticity +
                                                                is-aregulation of neuronal synaptic plasticity +
                                                                is-aregulation of synaptic metaplasticity +
                                                                is-aregulation of synaptic plasticity by chemical substance +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of signaling
                                        is-aregulation of synaptic transmission
                                                is-aregulation of synaptic plasticity
                                                        is-along term synaptic depression +
                                                        is-along-term synaptic potentiation +
                                                        is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                                is-anegative regulation of synaptic metaplasticity
                                                        is-apositive regulation of synaptic plasticity +
                                                        is-aregulation of neuronal synaptic plasticity +
                                                        is-aregulation of synaptic metaplasticity +
                                                        is-aregulation of synaptic plasticity by chemical substance +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological quality
                                is-aregulation of synaptic plasticity
                                        is-along term synaptic depression +
                                        is-along-term synaptic potentiation +
                                        is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                is-anegative regulation of synaptic metaplasticity
                                        is-apositive regulation of synaptic plasticity +
                                        is-aregulation of neuronal synaptic plasticity +
                                        is-aregulation of synaptic metaplasticity +
                                        is-aregulation of synaptic plasticity by chemical substance +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of synaptic transmission
                                is-aregulation of synaptic plasticity
                                        is-along term synaptic depression +
                                        is-along-term synaptic potentiation +
                                        is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                is-anegative regulation of synaptic metaplasticity
                                        is-apositive regulation of synaptic plasticity +
                                        is-aregulation of neuronal synaptic plasticity +
                                        is-aregulation of synaptic metaplasticity +
                                        is-aregulation of synaptic plasticity by chemical substance +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-aregulation of cell communication
                                        is-aregulation of synaptic transmission
                                                is-aregulation of synaptic plasticity
                                                        is-along term synaptic depression +
                                                        is-along-term synaptic potentiation +
                                                        is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                                is-anegative regulation of synaptic metaplasticity
                                                        is-apositive regulation of synaptic plasticity +
                                                        is-aregulation of neuronal synaptic plasticity +
                                                        is-aregulation of synaptic metaplasticity +
                                                        is-aregulation of synaptic plasticity by chemical substance +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        is-acell-cell signaling
                                                is-asynaptic transmission
                                                        regulatesregulation of synaptic transmission
                                                                is-aregulation of synaptic plasticity
                                                                        is-along term synaptic depression +
                                                                        is-along-term synaptic potentiation +
                                                                        is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                                                is-anegative regulation of synaptic metaplasticity
                                                                        is-apositive regulation of synaptic plasticity +
                                                                        is-aregulation of neuronal synaptic plasticity +
                                                                        is-aregulation of synaptic metaplasticity +
                                                                        is-aregulation of synaptic plasticity by chemical substance +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        regulatesregulation of cell communication
                                                is-aregulation of synaptic transmission
                                                        is-aregulation of synaptic plasticity
                                                                is-along term synaptic depression +
                                                                is-along-term synaptic potentiation +
                                                                is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                                        is-anegative regulation of synaptic metaplasticity
                                                                is-apositive regulation of synaptic plasticity +
                                                                is-aregulation of neuronal synaptic plasticity +
                                                                is-aregulation of synaptic metaplasticity +
                                                                is-aregulation of synaptic plasticity by chemical substance +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-aregulation of cell communication
                                        is-aregulation of synaptic transmission
                                                is-aregulation of synaptic plasticity
                                                        is-along term synaptic depression +
                                                        is-along-term synaptic potentiation +
                                                        is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                                is-anegative regulation of synaptic metaplasticity
                                                        is-apositive regulation of synaptic plasticity +
                                                        is-aregulation of neuronal synaptic plasticity +
                                                        is-aregulation of synaptic metaplasticity +
                                                        is-aregulation of synaptic plasticity by chemical substance +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of signaling
                                is-aregulation of synaptic transmission
                                        is-aregulation of synaptic plasticity
                                                is-along term synaptic depression +
                                                is-along-term synaptic potentiation +
                                                is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                        is-anegative regulation of synaptic metaplasticity
                                                is-apositive regulation of synaptic plasticity +
                                                is-aregulation of neuronal synaptic plasticity +
                                                is-aregulation of synaptic metaplasticity +
                                                is-aregulation of synaptic plasticity by chemical substance +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                is-acell-cell signaling
                                        is-asynaptic transmission
                                                regulatesregulation of synaptic transmission
                                                        is-aregulation of synaptic plasticity
                                                                is-along term synaptic depression +
                                                                is-along-term synaptic potentiation +
                                                                is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                                        is-anegative regulation of synaptic metaplasticity
                                                                is-apositive regulation of synaptic plasticity +
                                                                is-aregulation of neuronal synaptic plasticity +
                                                                is-aregulation of synaptic metaplasticity +
                                                                is-aregulation of synaptic plasticity by chemical substance +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                regulatesregulation of signaling
                                        is-aregulation of synaptic transmission
                                                is-aregulation of synaptic plasticity
                                                        is-along term synaptic depression +
                                                        is-along-term synaptic potentiation +
                                                        is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                                is-anegative regulation of synaptic metaplasticity
                                                        is-apositive regulation of synaptic plasticity +
                                                        is-aregulation of neuronal synaptic plasticity +
                                                        is-aregulation of synaptic metaplasticity +
                                                        is-aregulation of synaptic plasticity by chemical substance +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asynaptic transmission
                                regulatesregulation of synaptic transmission
                                        is-aregulation of synaptic plasticity
                                                is-along term synaptic depression +
                                                is-along-term synaptic potentiation +
                                                is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                        is-anegative regulation of synaptic metaplasticity
                                                is-apositive regulation of synaptic plasticity +
                                                is-aregulation of neuronal synaptic plasticity +
                                                is-aregulation of synaptic metaplasticity +
                                                is-aregulation of synaptic plasticity by chemical substance +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                is-acell-cell signaling
                                        is-asynaptic transmission
                                                regulatesregulation of synaptic transmission
                                                        is-aregulation of synaptic plasticity
                                                                is-along term synaptic depression +
                                                                is-along-term synaptic potentiation +
                                                                is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                                        is-anegative regulation of synaptic metaplasticity
                                                                is-apositive regulation of synaptic plasticity +
                                                                is-aregulation of neuronal synaptic plasticity +
                                                                is-aregulation of synaptic metaplasticity +
                                                                is-aregulation of synaptic plasticity by chemical substance +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                regulatesregulation of signaling
                                        is-aregulation of synaptic transmission
                                                is-aregulation of synaptic plasticity
                                                        is-along term synaptic depression +
                                                        is-along-term synaptic potentiation +
                                                        is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                                is-anegative regulation of synaptic metaplasticity
                                                        is-apositive regulation of synaptic plasticity +
                                                        is-aregulation of neuronal synaptic plasticity +
                                                        is-aregulation of synaptic metaplasticity +
                                                        is-aregulation of synaptic plasticity by chemical substance +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        is-acell-cell signaling
                                                is-asynaptic transmission
                                                        regulatesregulation of synaptic transmission
                                                                is-aregulation of synaptic plasticity
                                                                        is-along term synaptic depression +
                                                                        is-along-term synaptic potentiation +
                                                                        is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                                                is-anegative regulation of synaptic metaplasticity
                                                                        is-apositive regulation of synaptic plasticity +
                                                                        is-aregulation of neuronal synaptic plasticity +
                                                                        is-aregulation of synaptic metaplasticity +
                                                                        is-aregulation of synaptic plasticity by chemical substance +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        regulatesregulation of cell communication
                                                is-aregulation of synaptic transmission
                                                        is-aregulation of synaptic plasticity
                                                                is-along term synaptic depression +
                                                                is-along-term synaptic potentiation +
                                                                is-anegative regulation of synaptic plasticity [GO:0031914] (4 genes, 4 annotations)
                                                                        is-anegative regulation of synaptic metaplasticity
                                                                is-apositive regulation of synaptic plasticity +
                                                                is-aregulation of neuronal synaptic plasticity +
                                                                is-aregulation of synaptic metaplasticity +
                                                                is-aregulation of synaptic plasticity by chemical substance +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory