About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:lyase activity
Synonym: other lyase activity
GO id:GO:0016829
Definition:Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
CommentsNote that enzymes of class EC:4.99.-.- should also be annotated to this term.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-acatalysis of free radical formation +
                        is-acyclase activity +
                        is-adeaminase activity +
                        is-ademethylase activity +
                        is-afirst spliceosomal transesterification activity
                        is-aglycogen debranching enzyme activity +
                        is-ahydrolase activity +
                        is-aintegrase activity +
                        is-aisomerase activity +
                        is-aligase activity +
                        is-alyase activity [GO:0016829] (181 genes, 476 annotations)
                                is-a2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity
                                is-aalkylmercury lyase activity
                                is-acarbon phosphorus lyase activity
                                is-acarbon-carbon lyase activity +
                                is-acarbon-halide lyase activity +
                                is-acarbon-nitrogen lyase activity +
                                is-acarbon-oxygen lyase activity +
                                is-acarbon-sulfur lyase activity +
                                is-acobalt-precorrin-5A acetaldehyde-lyase activity
                                is-aferrochelatase activity +
                                is-aindoleacetaldoxime dehydratase activity
                                is-aphosphorus-oxygen lyase activity +
                                is-asirohydrochlorin cobaltochelatase activity
                        is-aMo-molybdopterin cofactor sulfurase activity
                        is-amolybdopterin synthase activity
                        is-aN-ethylammeline chlorohydrolase activity
                        is-aoxidoreductase activity +
                        is-aphenylacetaldehyde synthase activity
                        is-aphytoene synthase activity
                        is-aquinolinate synthetase A activity
                        is-aradical SAM enzyme activity +
                        is-arecombinase activity
                        is-aretroviral strand transfer activity
                        is-asecond spliceosomal transesterification activity
                        is-asite-specific recombinase activity +
                        is-asite-specific telomere resolvase activity
                        is-asmall protein activating enzyme activity +
                        is-atransferase activity +
                        is-atransposase activity
                        is-aUDP-L-rhamnose synthase activity
                        is-aversicolorin B synthase activity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory