About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Synonym: adenylate cyclase-modulating GPCR signaling pathway
Synonym: GPCR signaling pathway via cAMP second messenger
Synonym: GPCR signaling pathway via modulation of adenylate cyclase activity
Synonym: G protein signaling, coupled to cAMP nucleotide second messenger
Synonym: G-protein signaling, coupled to cAMP nucleotide second messenger
Synonym: G protein signaling, coupled to cyclic AMP nucleotide second messenger
Synonym: G-protein signaling, coupled to cyclic AMP nucleotide second messenger
Synonym: G protein signalling, coupled to cAMP nucleotide second messenger
Synonym: G-protein signalling, coupled to cAMP nucleotide second messenger
Synonym: G protein signalling, coupled to cyclic AMP nucleotide second messenger
Synonym: G-protein signalling, coupled to cyclic AMP nucleotide second messenger
GO id:GO:0007188
Definition:The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).
CommentsThis term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase activity. For steps upstream of adenylate cyclase activity, consider instead annotating to 'regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway ; GO:0010578.
Number of paths to term: 9

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aG-protein coupled receptor signaling pathway
                                                                is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
                                                                        is-aadenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (109 genes, 187 annotations)
                                                                                is-aadenylate cyclase-activating G-protein coupled receptor signaling pathway +
                                                                                is-aadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +
                                                                                part-ofregulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +
                                                                        is-aG-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aG-protein coupled receptor signaling pathway
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
                                                                is-aadenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (109 genes, 187 annotations)
                                                                        is-aadenylate cyclase-activating G-protein coupled receptor signaling pathway +
                                                                        is-aadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +
                                                                        part-ofregulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +
                                                                is-aG-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aG-protein coupled receptor signaling pathway
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
                                                                is-aadenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (109 genes, 187 annotations)
                                                                        is-aadenylate cyclase-activating G-protein coupled receptor signaling pathway +
                                                                        is-aadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +
                                                                        part-ofregulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +
                                                                is-aG-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aG-protein coupled receptor signaling pathway
                                                                is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
                                                                        is-aadenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (109 genes, 187 annotations)
                                                                                is-aadenylate cyclase-activating G-protein coupled receptor signaling pathway +
                                                                                is-aadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +
                                                                                part-ofregulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +
                                                                        is-aG-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aG-protein coupled receptor signaling pathway
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
                                                                is-aadenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (109 genes, 187 annotations)
                                                                        is-aadenylate cyclase-activating G-protein coupled receptor signaling pathway +
                                                                        is-aadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +
                                                                        part-ofregulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +
                                                                is-aG-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aG-protein coupled receptor signaling pathway
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
                                                                is-aadenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (109 genes, 187 annotations)
                                                                        is-aadenylate cyclase-activating G-protein coupled receptor signaling pathway +
                                                                        is-aadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +
                                                                        part-ofregulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +
                                                                is-aG-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aG-protein coupled receptor signaling pathway
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
                                                                is-aadenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (109 genes, 187 annotations)
                                                                        is-aadenylate cyclase-activating G-protein coupled receptor signaling pathway +
                                                                        is-aadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +
                                                                        part-ofregulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +
                                                                is-aG-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aG-protein coupled receptor signaling pathway
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
                                                                is-aadenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (109 genes, 187 annotations)
                                                                        is-aadenylate cyclase-activating G-protein coupled receptor signaling pathway +
                                                                        is-aadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +
                                                                        part-ofregulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +
                                                                is-aG-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aG-protein coupled receptor signaling pathway
                                                                is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
                                                                        is-aadenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (109 genes, 187 annotations)
                                                                                is-aadenylate cyclase-activating G-protein coupled receptor signaling pathway +
                                                                                is-aadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +
                                                                                part-ofregulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +
                                                                        is-aG-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory