| GO term: | adenylate cyclase-modulating G-protein coupled receptor signaling pathway |
| Synonym: | adenylate cyclase-modulating GPCR signaling pathway |
| Synonym: | GPCR signaling pathway via cAMP second messenger |
| Synonym: | GPCR signaling pathway via modulation of adenylate cyclase activity |
| Synonym: | G protein signaling, coupled to cAMP nucleotide second messenger |
| Synonym: | G-protein signaling, coupled to cAMP nucleotide second messenger |
| Synonym: | G protein signaling, coupled to cyclic AMP nucleotide second messenger |
| Synonym: | G-protein signaling, coupled to cyclic AMP nucleotide second messenger |
| Synonym: | G protein signalling, coupled to cAMP nucleotide second messenger |
| Synonym: | G-protein signalling, coupled to cAMP nucleotide second messenger |
| Synonym: | G protein signalling, coupled to cyclic AMP nucleotide second messenger |
| Synonym: | G-protein signalling, coupled to cyclic AMP nucleotide second messenger |
| GO id: | GO:0007188 |
| Definition: | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP). |
| Comments | This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase activity. For steps upstream of adenylate cyclase activity, consider instead annotating to 'regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway ; GO:0010578. |
| Number of paths to term: | 10 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengeradenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (99 genes, 162 annotations)adenylate cyclase-activating G-protein coupled receptor signaling pathway +adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerbiological_processcellular processregulation of cellular processsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengeradenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (99 genes, 162 annotations)adenylate cyclase-activating G-protein coupled receptor signaling pathway +adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerbiological_processcellular processsingle-organism cellular processcell communicationsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengeradenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (99 genes, 162 annotations)adenylate cyclase-activating G-protein coupled receptor signaling pathway +adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerbiological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengeradenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (99 genes, 162 annotations)adenylate cyclase-activating G-protein coupled receptor signaling pathway +adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerbiological_processregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengeradenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (99 genes, 162 annotations)adenylate cyclase-activating G-protein coupled receptor signaling pathway +adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerbiological_processresponse to stimuluscellular response to stimulussignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengeradenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (99 genes, 162 annotations)adenylate cyclase-activating G-protein coupled receptor signaling pathway +adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerbiological_processsignalingsingle organism signalingsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengeradenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (99 genes, 162 annotations)adenylate cyclase-activating G-protein coupled receptor signaling pathway +adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerbiological_processsingle-organism processsingle organism signalingsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengeradenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (99 genes, 162 annotations)adenylate cyclase-activating G-protein coupled receptor signaling pathway +adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerbiological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengeradenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (99 genes, 162 annotations)adenylate cyclase-activating G-protein coupled receptor signaling pathway +adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerbiological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengeradenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] (99 genes, 162 annotations)adenylate cyclase-activating G-protein coupled receptor signaling pathway +adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway +regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway +G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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