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Gene Ontology Browser
Term Detail
GO term:activation-induced cell death of T cells
Synonym: activated T cell apoptosis
Synonym: activation-induced cell death of T-cells
Synonym: activation-induced cell death of T lymphocytes
Synonym: activation-induced cell death of T-lymphocytes
Synonym: AICD
Synonym: antigen-driven apoptosis
GO id:GO:0006924
Definition:A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors.
Number of paths to term: 5

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological quality
                                is-ahomeostatic process
                                        is-ahomeostasis of number of cells
                                                is-aleukocyte homeostasis
                                                        is-alymphocyte homeostasis
                                                                is-aT cell homeostasis
                                                                        part-ofactivated T cell autonomous cell death +
                                                                        part-ofactivation-induced cell death of T cells [GO:0006924] (13 genes, 14 annotations)
                                                                                negatively-regulatesnegative regulation of activation-induced cell death of T cells
                                                                                positively-regulatespositive regulation of activation-induced cell death of T cells
                                                                                regulatesregulation of activation-induced cell death of T cells +
                                                                        part-ofT cell homeostatic proliferation +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        is-acell-type specific apoptotic process
                                                                is-aleukocyte apoptotic process
                                                                        is-alymphocyte apoptotic process
                                                                                is-aT cell apoptotic process
                                                                                        is-aactivated T cell autonomous cell death +
                                                                                        is-aactivation-induced cell death of T cells [GO:0006924] (13 genes, 14 annotations)
                                                                                                negatively-regulatesnegative regulation of activation-induced cell death of T cells
                                                                                                positively-regulatespositive regulation of activation-induced cell death of T cells
                                                                                                regulatesregulation of activation-induced cell death of T cells +
                                                                                        is-acytotoxic T cell apoptotic process
                                                                                        negatively-regulatesnegative regulation of T cell apoptotic process +
                                                                                        positively-regulatespositive regulation of T cell apoptotic process +
                                                                                        regulatesregulation of T cell apoptotic process +
                                                                                        is-aregulatory T cell apoptotic process
                                                                                        is-athymocyte apoptotic process +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aleukocyte homeostasis
                                is-alymphocyte homeostasis
                                        is-aT cell homeostasis
                                                part-ofactivated T cell autonomous cell death +
                                                part-ofactivation-induced cell death of T cells [GO:0006924] (13 genes, 14 annotations)
                                                        negatively-regulatesnegative regulation of activation-induced cell death of T cells
                                                        positively-regulatespositive regulation of activation-induced cell death of T cells
                                                        regulatesregulation of activation-induced cell death of T cells +
                                                part-ofT cell homeostatic proliferation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-adeath
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        is-acell-type specific apoptotic process
                                                                is-aleukocyte apoptotic process
                                                                        is-alymphocyte apoptotic process
                                                                                is-aT cell apoptotic process
                                                                                        is-aactivated T cell autonomous cell death +
                                                                                        is-aactivation-induced cell death of T cells [GO:0006924] (13 genes, 14 annotations)
                                                                                                negatively-regulatesnegative regulation of activation-induced cell death of T cells
                                                                                                positively-regulatespositive regulation of activation-induced cell death of T cells
                                                                                                regulatesregulation of activation-induced cell death of T cells +
                                                                                        is-acytotoxic T cell apoptotic process
                                                                                        negatively-regulatesnegative regulation of T cell apoptotic process +
                                                                                        positively-regulatespositive regulation of T cell apoptotic process +
                                                                                        regulatesregulation of T cell apoptotic process +
                                                                                        is-aregulatory T cell apoptotic process
                                                                                        is-athymocyte apoptotic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        is-acell-type specific apoptotic process
                                                                is-aleukocyte apoptotic process
                                                                        is-alymphocyte apoptotic process
                                                                                is-aT cell apoptotic process
                                                                                        is-aactivated T cell autonomous cell death +
                                                                                        is-aactivation-induced cell death of T cells [GO:0006924] (13 genes, 14 annotations)
                                                                                                negatively-regulatesnegative regulation of activation-induced cell death of T cells
                                                                                                positively-regulatespositive regulation of activation-induced cell death of T cells
                                                                                                regulatesregulation of activation-induced cell death of T cells +
                                                                                        is-acytotoxic T cell apoptotic process
                                                                                        negatively-regulatesnegative regulation of T cell apoptotic process +
                                                                                        positively-regulatespositive regulation of T cell apoptotic process +
                                                                                        regulatesregulation of T cell apoptotic process +
                                                                                        is-aregulatory T cell apoptotic process
                                                                                        is-athymocyte apoptotic process +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory