| GO term: | creatine biosynthetic process |
| Synonym: | creatine anabolism |
| Synonym: | creatine biosynthesis |
| Synonym: | creatine formation |
| Synonym: | creatine synthesis |
| GO id: | GO:0006601 |
| Definition: | The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle. |
| Number of paths to term: | 80 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship