About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:creatine biosynthetic process
Synonym: creatine anabolism
Synonym: creatine biosynthesis
Synonym: creatine formation
Synonym: creatine synthesis
GO id:GO:0006601
Definition:The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.
Number of paths to term: 6

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-abiosynthetic process
                                is-aorganic substance biosynthetic process
                                        is-aorganonitrogen compound biosynthetic process
                                                is-acellular modified amino acid biosynthetic process
                                                        is-a(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine biosynthetic process from asparagine
                                                        is-a4-hydroxyproline biosynthetic process
                                                        is-aaerobactin biosynthetic process
                                                        is-acellular modified histidine biosynthetic process +
                                                        is-acoenzyme B biosynthetic process
                                                        is-acreatine biosynthetic process [GO:0006601] (2 genes, 4 annotations)
                                                        is-adeoxyhypusine biosynthetic process from spermidine
                                                        is-afolic acid-containing compound biosynthetic process +
                                                        is-aglutathione biosynthetic process +
                                                        is-aglycine betaine biosynthetic process +
                                                        is-aL-dopa biosynthetic process +
                                                        is-alincomycin biosynthetic process
                                                        is-aN-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthetic process +
                                                        is-aO3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process
                                                        is-aochratoxin A biosynthetic process
                                                        is-apeptidyl-1-thioglycine biosynthetic process from peptidyl-glycine +
                                                        is-apeptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine
                                                        is-aphosphagen biosynthetic process +
                                                        is-aphosphatidylserine biosynthetic process +
                                                        is-aprenylcysteine biosynthetic process
                                                        is-apyrrolysine biosynthetic process
                                                        is-asarcosine biosynthetic process
                                                        is-astachydrine biosynthetic process


obsolete Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-anitrogen compound metabolic process
                                is-aorganonitrogen compound metabolic process
                                        is-acreatine metabolic process
                                                is-acreatine biosynthetic process [GO:0006601] (2 genes, 4 annotations)
                                                is-aglycine catabolic process to creatine


obsolete Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-anitrogen compound metabolic process
                                is-aorganonitrogen compound metabolic process
                                        is-aorganonitrogen compound biosynthetic process
                                                is-acellular modified amino acid biosynthetic process
                                                        is-a(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine biosynthetic process from asparagine
                                                        is-a4-hydroxyproline biosynthetic process
                                                        is-aaerobactin biosynthetic process
                                                        is-acellular modified histidine biosynthetic process +
                                                        is-acoenzyme B biosynthetic process
                                                        is-acreatine biosynthetic process [GO:0006601] (2 genes, 4 annotations)
                                                        is-adeoxyhypusine biosynthetic process from spermidine
                                                        is-afolic acid-containing compound biosynthetic process +
                                                        is-aglutathione biosynthetic process +
                                                        is-aglycine betaine biosynthetic process +
                                                        is-aL-dopa biosynthetic process +
                                                        is-alincomycin biosynthetic process
                                                        is-aN-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthetic process +
                                                        is-aO3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process
                                                        is-aochratoxin A biosynthetic process
                                                        is-apeptidyl-1-thioglycine biosynthetic process from peptidyl-glycine +
                                                        is-apeptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine
                                                        is-aphosphagen biosynthetic process +
                                                        is-aphosphatidylserine biosynthetic process +
                                                        is-aprenylcysteine biosynthetic process
                                                        is-apyrrolysine biosynthetic process
                                                        is-asarcosine biosynthetic process
                                                        is-astachydrine biosynthetic process


obsolete Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganic substance biosynthetic process
                                        is-aorganonitrogen compound biosynthetic process
                                                is-acellular modified amino acid biosynthetic process
                                                        is-a(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine biosynthetic process from asparagine
                                                        is-a4-hydroxyproline biosynthetic process
                                                        is-aaerobactin biosynthetic process
                                                        is-acellular modified histidine biosynthetic process +
                                                        is-acoenzyme B biosynthetic process
                                                        is-acreatine biosynthetic process [GO:0006601] (2 genes, 4 annotations)
                                                        is-adeoxyhypusine biosynthetic process from spermidine
                                                        is-afolic acid-containing compound biosynthetic process +
                                                        is-aglutathione biosynthetic process +
                                                        is-aglycine betaine biosynthetic process +
                                                        is-aL-dopa biosynthetic process +
                                                        is-alincomycin biosynthetic process
                                                        is-aN-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthetic process +
                                                        is-aO3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process
                                                        is-aochratoxin A biosynthetic process
                                                        is-apeptidyl-1-thioglycine biosynthetic process from peptidyl-glycine +
                                                        is-apeptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine
                                                        is-aphosphagen biosynthetic process +
                                                        is-aphosphatidylserine biosynthetic process +
                                                        is-aprenylcysteine biosynthetic process
                                                        is-apyrrolysine biosynthetic process
                                                        is-asarcosine biosynthetic process
                                                        is-astachydrine biosynthetic process


obsolete Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganonitrogen compound metabolic process
                                        is-acreatine metabolic process
                                                is-acreatine biosynthetic process [GO:0006601] (2 genes, 4 annotations)
                                                is-aglycine catabolic process to creatine


obsolete Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganonitrogen compound metabolic process
                                        is-aorganonitrogen compound biosynthetic process
                                                is-acellular modified amino acid biosynthetic process
                                                        is-a(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine biosynthetic process from asparagine
                                                        is-a4-hydroxyproline biosynthetic process
                                                        is-aaerobactin biosynthetic process
                                                        is-acellular modified histidine biosynthetic process +
                                                        is-acoenzyme B biosynthetic process
                                                        is-acreatine biosynthetic process [GO:0006601] (2 genes, 4 annotations)
                                                        is-adeoxyhypusine biosynthetic process from spermidine
                                                        is-afolic acid-containing compound biosynthetic process +
                                                        is-aglutathione biosynthetic process +
                                                        is-aglycine betaine biosynthetic process +
                                                        is-aL-dopa biosynthetic process +
                                                        is-alincomycin biosynthetic process
                                                        is-aN-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthetic process +
                                                        is-aO3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process
                                                        is-aochratoxin A biosynthetic process
                                                        is-apeptidyl-1-thioglycine biosynthetic process from peptidyl-glycine +
                                                        is-apeptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine
                                                        is-aphosphagen biosynthetic process +
                                                        is-aphosphatidylserine biosynthetic process +
                                                        is-aprenylcysteine biosynthetic process
                                                        is-apyrrolysine biosynthetic process
                                                        is-asarcosine biosynthetic process
                                                        is-astachydrine biosynthetic process


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory