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Term Detail
GO term:signal transducer activity, downstream of receptor
Synonym: intracellular signal transducer activity
Synonym: receptor signaling protein activity
Synonym: receptor signalling protein activity
GO id:GO:0005057
Definition:Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell.
CommentsThis term is intended for annotation of signal transducers that act directly or indirectly downstream of a receptor. For receptors themselves, consider annotating to the term 'receptor activity ; GO:0004872'.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship

                is-asignal transducer activity
                        is-acysteine-type endopeptidase activity involved in apoptotic signaling pathway
                        is-ahistidine phosphotransfer kinase activity
                        is-aIkappaB kinase activity
                        is-aion channel regulator activity involved in G-protein coupled receptor signaling pathway +
                        is-alight-activated voltage-gated calcium channel activity
                        is-aMAP kinase kinase activity +
                        is-aMAP kinase phosphatase activity involved in regulation of innate immune response
                        is-anetrin receptor binding
                        is-aphosphorelay response regulator activity
                        is-areceptor agonist activity +
                        is-aRNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding +
                        is-asignal transducer activity, downstream of receptor [GO:0005057] (126 genes, 172 annotations)
                                is-asignal transducer, downstream of receptor, with protein tyrosine kinase activity
                                is-asignal transducer, downstream of receptor, with protein tyrosine phosphatase activity
                                is-asignal transducer, downstream of receptor, with serine/threonine kinase activity +
                                is-asignal transducer, downstream of receptor, with serine/threonine phosphatase activity
                                is-atransforming growth factor beta receptor, cytoplasmic mediator activity +
                        is-asignaling receptor activity +
                        is-atransmembrane receptor protein tyrosine kinase activator activity
                        is-atransmembrane receptor protein tyrosine kinase adaptor activity

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.08
The Jackson Laboratory