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Gene Ontology Browser
Term Detail
GO term:scavenger receptor activity
Synonym: macrophage receptor activity
GO id:GO:0005044
Definition:Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs).
CommentsNote that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0008329' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-areceptor activity
                        is-acargo receptor activity
                                is-aalpha-2 macroglobulin receptor activity
                                is-aasialoglycoprotein receptor activity
                                is-aferritin receptor activity
                                is-alactoferrin receptor activity
                                is-alipoprotein particle receptor activity +
                                is-ascavenger receptor activity [GO:0005044] (41 genes, 42 annotations)
                                is-atransferrin receptor activity
                                is-avitellogenin receptor activity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory