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Term Detail
GO term:chemokine receptor activity
GO id:GO:0004950
Definition:Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
Number of paths to term: 6

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-amolecular transducer activity
                        is-asignal transducer activity
                                is-asignaling receptor activity
                                        is-apeptide receptor activity
                                                is-aG-protein coupled peptide receptor activity
                                                        is-aG-protein coupled chemoattractant receptor activity
                                                                is-achemokine receptor activity [GO:0004950] (25 genes, 55 annotations)
                                                                        is-aC-C chemokine receptor activity +
                                                                        is-aC-X-C chemokine receptor activity +
                                                                        is-aC-X3-C chemokine receptor activity


Gene_Ontology
        is-amolecular_function
                is-amolecular transducer activity
                        is-asignal transducer activity
                                is-asignaling receptor activity
                                        is-atransmembrane signaling receptor activity
                                                is-acytokine receptor activity
                                                        is-achemokine receptor activity [GO:0004950] (25 genes, 55 annotations)
                                                                is-aC-C chemokine receptor activity +
                                                                is-aC-X-C chemokine receptor activity +
                                                                is-aC-X3-C chemokine receptor activity
                                                        is-aciliary neurotrophic factor receptor activity +
                                                        is-aerythropoietin receptor activity
                                                        is-aglial cell-derived neurotrophic factor receptor activity
                                                        is-agranulocyte colony-stimulating factor receptor activity
                                                        is-agranulocyte macrophage colony-stimulating factor receptor activity
                                                        is-agrowth hormone receptor activity
                                                        is-ahigh mobility group box 1 receptor activity
                                                        is-ainterferon receptor activity +
                                                        is-ainterleukin-1 receptor activity +
                                                        is-ainterleukin-10 receptor activity
                                                        is-ainterleukin-11 receptor activity
                                                        is-ainterleukin-12 receptor activity
                                                        is-ainterleukin-13 receptor activity
                                                        is-ainterleukin-14 receptor activity
                                                        is-ainterleukin-15 receptor activity
                                                        is-ainterleukin-16 receptor activity
                                                        is-ainterleukin-17 receptor activity +
                                                        is-ainterleukin-18 receptor activity
                                                        is-ainterleukin-19 receptor activity
                                                        is-ainterleukin-2 receptor activity
                                                        is-ainterleukin-20 receptor activity
                                                        is-ainterleukin-21 receptor activity
                                                        is-ainterleukin-22 receptor activity
                                                        is-ainterleukin-23 receptor activity
                                                        is-ainterleukin-24 receptor activity
                                                        is-ainterleukin-25 receptor activity
                                                        is-ainterleukin-26 receptor activity
                                                        is-ainterleukin-27 receptor activity
                                                        is-ainterleukin-3 receptor activity
                                                        is-ainterleukin-33 receptor activity
                                                        is-ainterleukin-35 receptor activity
                                                        is-ainterleukin-4 receptor activity
                                                        is-ainterleukin-5 receptor activity
                                                        is-ainterleukin-6 receptor activity
                                                        is-ainterleukin-7 receptor activity
                                                        is-ainterleukin-9 receptor activity
                                                        is-aleptin receptor activity
                                                        is-aoncostatin-M receptor activity
                                                        is-aprolactin receptor activity
                                                        is-athrombopoietin receptor activity


Gene_Ontology
        is-amolecular_function
                is-amolecular transducer activity
                        is-asignal transducer activity
                                is-asignaling receptor activity
                                        is-atransmembrane signaling receptor activity
                                                is-aG-protein coupled receptor activity
                                                        is-aG-protein coupled peptide receptor activity
                                                                is-aG-protein coupled chemoattractant receptor activity
                                                                        is-achemokine receptor activity [GO:0004950] (25 genes, 55 annotations)
                                                                                is-aC-C chemokine receptor activity +
                                                                                is-aC-X-C chemokine receptor activity +
                                                                                is-aC-X3-C chemokine receptor activity


Gene_Ontology
        is-amolecular_function
                is-areceptor activity
                        is-asignaling receptor activity
                                is-apeptide receptor activity
                                        is-aG-protein coupled peptide receptor activity
                                                is-aG-protein coupled chemoattractant receptor activity
                                                        is-achemokine receptor activity [GO:0004950] (25 genes, 55 annotations)
                                                                is-aC-C chemokine receptor activity +
                                                                is-aC-X-C chemokine receptor activity +
                                                                is-aC-X3-C chemokine receptor activity


Gene_Ontology
        is-amolecular_function
                is-areceptor activity
                        is-asignaling receptor activity
                                is-atransmembrane signaling receptor activity
                                        is-acytokine receptor activity
                                                is-achemokine receptor activity [GO:0004950] (25 genes, 55 annotations)
                                                        is-aC-C chemokine receptor activity +
                                                        is-aC-X-C chemokine receptor activity +
                                                        is-aC-X3-C chemokine receptor activity
                                                is-aciliary neurotrophic factor receptor activity +
                                                is-aerythropoietin receptor activity
                                                is-aglial cell-derived neurotrophic factor receptor activity
                                                is-agranulocyte colony-stimulating factor receptor activity
                                                is-agranulocyte macrophage colony-stimulating factor receptor activity
                                                is-agrowth hormone receptor activity
                                                is-ahigh mobility group box 1 receptor activity
                                                is-ainterferon receptor activity +
                                                is-ainterleukin-1 receptor activity +
                                                is-ainterleukin-10 receptor activity
                                                is-ainterleukin-11 receptor activity
                                                is-ainterleukin-12 receptor activity
                                                is-ainterleukin-13 receptor activity
                                                is-ainterleukin-14 receptor activity
                                                is-ainterleukin-15 receptor activity
                                                is-ainterleukin-16 receptor activity
                                                is-ainterleukin-17 receptor activity +
                                                is-ainterleukin-18 receptor activity
                                                is-ainterleukin-19 receptor activity
                                                is-ainterleukin-2 receptor activity
                                                is-ainterleukin-20 receptor activity
                                                is-ainterleukin-21 receptor activity
                                                is-ainterleukin-22 receptor activity
                                                is-ainterleukin-23 receptor activity
                                                is-ainterleukin-24 receptor activity
                                                is-ainterleukin-25 receptor activity
                                                is-ainterleukin-26 receptor activity
                                                is-ainterleukin-27 receptor activity
                                                is-ainterleukin-3 receptor activity
                                                is-ainterleukin-33 receptor activity
                                                is-ainterleukin-35 receptor activity
                                                is-ainterleukin-4 receptor activity
                                                is-ainterleukin-5 receptor activity
                                                is-ainterleukin-6 receptor activity
                                                is-ainterleukin-7 receptor activity
                                                is-ainterleukin-9 receptor activity
                                                is-aleptin receptor activity
                                                is-aoncostatin-M receptor activity
                                                is-aprolactin receptor activity
                                                is-athrombopoietin receptor activity


Gene_Ontology
        is-amolecular_function
                is-areceptor activity
                        is-asignaling receptor activity
                                is-atransmembrane signaling receptor activity
                                        is-aG-protein coupled receptor activity
                                                is-aG-protein coupled peptide receptor activity
                                                        is-aG-protein coupled chemoattractant receptor activity
                                                                is-achemokine receptor activity [GO:0004950] (25 genes, 55 annotations)
                                                                        is-aC-C chemokine receptor activity +
                                                                        is-aC-X-C chemokine receptor activity +
                                                                        is-aC-X3-C chemokine receptor activity


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory