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Gene Ontology Browser
Term Detail
GO term:cyclin-dependent protein serine/threonine kinase activity
Synonym: ATP:cyclin phosphotransferase activity
Synonym: cdc2 kinase activity
Synonym: CDK
Synonym: cdk-activating kinase activity
Synonym: Cdk-activating protein kinase activity
Synonym: CDK activity
Synonym: CDK, catalytic subunit activity
Synonym: cyclin-A associated kinase activity
Synonym: cyclin D-cdk6 kinase activity
Synonym: cyclin D-dependent kinase activity
Synonym: cyclin-dependent kinase-2 activity
Synonym: cyclin-dependent kinase-4 activity
Synonym: cyclin-dependent kinase 6 activity
Synonym: cyclin-dependent kinase activity
Synonym: cyclin-dependent protein kinase activity
Synonym: cyclin-dependent protein kinase, intrinsic catalyst activity
Synonym: cyclin E kinase activity
Synonym: D-type cyclin kinase activity
Synonym: neuronal cdc2-like kinase activity
GO id:GO:0004693
Definition:Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
Number of paths to term: 4

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring phosphorus-containing groups
                                        is-akinase activity
                                                is-aprotein kinase activity
                                                        is-acyclin-dependent protein kinase activity
                                                                is-acyclin-dependent protein serine/threonine kinase activity [GO:0004693] (31 genes, 35 annotations)
                                                                is-acyclin-dependent protein tyrosine kinase activity


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring phosphorus-containing groups
                                        is-akinase activity
                                                is-aprotein kinase activity
                                                        is-aprotein serine/threonine kinase activity
                                                                is-a3-phosphoinositide-dependent protein kinase activity
                                                                is-aAMP-activated protein kinase activity
                                                                is-acalcium-dependent protein serine/threonine kinase activity +
                                                                is-acalmodulin-dependent protein kinase activity +
                                                                is-acyclic nucleotide-dependent protein kinase activity +
                                                                is-acyclin-dependent protein serine/threonine kinase activity [GO:0004693] (31 genes, 35 annotations)
                                                                is-aDNA-dependent protein kinase activity
                                                                is-aeukaryotic translation initiation factor 2alpha kinase activity
                                                                is-aFas-activated serine/threonine kinase activity
                                                                is-aG-protein coupled receptor kinase activity
                                                                is-aGoodpasture-antigen-binding protein kinase activity
                                                                is-aGTP-dependent protein kinase activity
                                                                is-ahistone serine kinase activity +
                                                                is-ahistone threonine kinase activity +
                                                                is-aIkappaB kinase activity
                                                                is-amyosin light chain kinase activity
                                                                is-aprotein kinase C activity +
                                                                is-areceptor signaling protein serine/threonine kinase activity +
                                                                is-aRho-dependent protein serine/threonine kinase activity
                                                                is-aribosomal protein S6 kinase activity
                                                                is-aRNA polymerase II carboxy-terminal domain kinase activity
                                                                is-atransmembrane receptor protein serine/threonine kinase activity +


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring phosphorus-containing groups
                                        is-aphosphotransferase activity, alcohol group as acceptor
                                                is-aprotein kinase activity
                                                        is-acyclin-dependent protein kinase activity
                                                                is-acyclin-dependent protein serine/threonine kinase activity [GO:0004693] (31 genes, 35 annotations)
                                                                is-acyclin-dependent protein tyrosine kinase activity


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring phosphorus-containing groups
                                        is-aphosphotransferase activity, alcohol group as acceptor
                                                is-aprotein kinase activity
                                                        is-aprotein serine/threonine kinase activity
                                                                is-a3-phosphoinositide-dependent protein kinase activity
                                                                is-aAMP-activated protein kinase activity
                                                                is-acalcium-dependent protein serine/threonine kinase activity +
                                                                is-acalmodulin-dependent protein kinase activity +
                                                                is-acyclic nucleotide-dependent protein kinase activity +
                                                                is-acyclin-dependent protein serine/threonine kinase activity [GO:0004693] (31 genes, 35 annotations)
                                                                is-aDNA-dependent protein kinase activity
                                                                is-aeukaryotic translation initiation factor 2alpha kinase activity
                                                                is-aFas-activated serine/threonine kinase activity
                                                                is-aG-protein coupled receptor kinase activity
                                                                is-aGoodpasture-antigen-binding protein kinase activity
                                                                is-aGTP-dependent protein kinase activity
                                                                is-ahistone serine kinase activity +
                                                                is-ahistone threonine kinase activity +
                                                                is-aIkappaB kinase activity
                                                                is-amyosin light chain kinase activity
                                                                is-aprotein kinase C activity +
                                                                is-areceptor signaling protein serine/threonine kinase activity +
                                                                is-aRho-dependent protein serine/threonine kinase activity
                                                                is-aribosomal protein S6 kinase activity
                                                                is-aRNA polymerase II carboxy-terminal domain kinase activity
                                                                is-atransmembrane receptor protein serine/threonine kinase activity +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory