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Gene Ontology Browser
Term Detail
GO term:cytochrome-c oxidase activity
Synonym: aa3-type cytochrome c oxidase
Synonym: ba3-type cytochrome c oxidase
Synonym: caa3-type cytochrome c oxidase
Synonym: cbb3-type cytochrome c oxidase
Synonym: complex IV (mitochondrial electron transport) activity
Synonym: cytochrome a3 activity
Synonym: cytochrome aa3 activity
Synonym: cytochrome c oxidase activity
Synonym: cytochrome oxidase activity
Synonym: ferrocytochrome c oxidase
Synonym: ferrocytochrome-c:oxygen oxidoreductase
Synonym: indophenolase
Synonym: indophenol oxidase
Synonym: NADH cytochrome c oxidase
Synonym: warburg's respiratory enzyme activity
GO id:GO:0004129
Definition:Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
CommentsThe reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment.
Number of paths to term: 5

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-aoxidoreductase activity
                                is-aheme-copper terminal oxidase activity
                                        is-acytochrome bo3 ubiquinol oxidase activity
                                        is-acytochrome o ubiquinol oxidase activity
                                        is-acytochrome-c oxidase activity [GO:0004129] (24 genes, 25 annotations)


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-aoxidoreductase activity
                                is-aoxidoreductase activity, acting on a heme group of donors
                                        is-aoxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
                                                is-acytochrome-c oxidase activity [GO:0004129] (24 genes, 25 annotations)


Gene_Ontology
        is-amolecular_function
                is-aelectron carrier activity
                        is-acytochrome-c oxidase activity [GO:0004129] (24 genes, 25 annotations)
                        is-aelectron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
                        is-aelectron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity
                        is-aelectron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity
                        is-aelectron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity
                        is-aelectron transporter, transferring electrons within cytochrome c oxidase complex activity
                        is-aelectron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
                        is-aelectron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-ainorganic cation transmembrane transporter activity
                                                                is-amonovalent inorganic cation transmembrane transporter activity
                                                                        is-ahydrogen ion transmembrane transporter activity
                                                                                is-a2-keto-3-deoxygluconate:hydrogen symporter activity
                                                                                is-aalpha-ketoglutarate:hydrogen symporter activity
                                                                                is-acytochrome-c oxidase activity [GO:0004129] (24 genes, 25 annotations)
                                                                                is-ahydrogen-exporting ATPase activity, phosphorylative mechanism
                                                                                is-ahydrogen:potassium-exchanging ATPase activity
                                                                                is-alactate:hydrogen symporter activity
                                                                                is-amalate:hydrogen symporter activity
                                                                                is-aNAD(P)+ transhydrogenase (B-specific) activity
                                                                                is-anitrate:hydrogen symporter activity
                                                                                is-aphosphate:hydrogen symporter activity
                                                                                is-apotassium:hydrogen symporter activity
                                                                                is-aproton-transporting ATP synthase activity, rotational mechanism
                                                                                is-aproton-transporting ATPase activity, rotational mechanism
                                                                                is-ashikimate:hydrogen symporter activity
                                                                                is-asolute:hydrogen antiporter activity +
                                                                                is-asuccinate:hydrogen symporter activity
                                                                                is-asulfate:hydrogen symporter activity +
                                                                                is-aubiquinol-cytochrome-c reductase activity


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-ainorganic cation transmembrane transporter activity
                                                                is-amonovalent inorganic cation transmembrane transporter activity
                                                                        is-ahydrogen ion transmembrane transporter activity
                                                                                is-a2-keto-3-deoxygluconate:hydrogen symporter activity
                                                                                is-aalpha-ketoglutarate:hydrogen symporter activity
                                                                                is-acytochrome-c oxidase activity [GO:0004129] (24 genes, 25 annotations)
                                                                                is-ahydrogen-exporting ATPase activity, phosphorylative mechanism
                                                                                is-ahydrogen:potassium-exchanging ATPase activity
                                                                                is-alactate:hydrogen symporter activity
                                                                                is-amalate:hydrogen symporter activity
                                                                                is-aNAD(P)+ transhydrogenase (B-specific) activity
                                                                                is-anitrate:hydrogen symporter activity
                                                                                is-aphosphate:hydrogen symporter activity
                                                                                is-apotassium:hydrogen symporter activity
                                                                                is-aproton-transporting ATP synthase activity, rotational mechanism
                                                                                is-aproton-transporting ATPase activity, rotational mechanism
                                                                                is-ashikimate:hydrogen symporter activity
                                                                                is-asolute:hydrogen antiporter activity +
                                                                                is-asuccinate:hydrogen symporter activity
                                                                                is-asulfate:hydrogen symporter activity +
                                                                                is-aubiquinol-cytochrome-c reductase activity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory