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Term Detail
GO term:gamma-glutamyltransferase activity
Synonym: (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity
Synonym: alpha-glutamyl transpeptidase activity
Synonym: gamma-glutamyl peptidyltransferase activity
Synonym: gamma-glutamyl transpeptidase activity
Synonym: gamma-GPT
Synonym: gamma-GT
Synonym: gamma-GTP
Synonym: glutamyl transpeptidase activity
Synonym: L-gamma-glutamyltransferase activity
Synonym: L-gamma-glutamyl transpeptidase activity
Synonym: L-glutamyltransferase activity
GO id:GO:0003840
Definition:Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid.
CommentsThe gene family commonly referred to as gamma-glutamyl transferases (GGT) catalyze hydrolysis of gamma-glutamyl bonds in gamma-glutamyl compounds such as glutathione. In a test tube one can set up conditions in which the enzyme will transfer the gamma-glutamyl portion of the substrate to an acceptor molecule, but this requires non-physiologic conditions, including millmolar concentrations of an acceptor such as glygly. This reaction is used in assays to detect the presence of the enzyme, but is not a physiological function of members of the GGT family (PMC4388159), which should be annotated to a suitable hydrolysis term instead (e.g. glutathione hydrolase activity).
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship

                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring acyl groups
                                        is-atransferase activity, transferring amino-acyl groups
                                                is-aagaritine gamma-glutamyltransferase activity
                                                is-aalanylphosphatidylglycerol synthase activity
                                                is-aarginyltransferase activity
                                                is-aaspartyltransferase activity
                                                is-aD-alanine gamma-glutamyltransferase activity
                                                is-aD-glutamyltransferase activity
                                                is-aeoxin D4 synthase activity
                                                is-agamma-glutamylcyclotransferase activity
                                                is-agamma-glutamyltransferase activity [GO:0003840] (4 genes, 4 annotations)
                                                is-aglutaminyl-peptide cyclotransferase activity
                                                is-aglutathione gamma-glutamylcysteinyltransferase activity
                                                is-ahomophytochelatin synthase activity
                                                is-aleucyltransferase activity
                                                is-alysyltransferase activity
                                                is-apeptidyltransferase activity
                                                is-aprotein-glutamine gamma-glutamyltransferase activity
                                                is-aprotein-lysine lysyltransferase activity
                                                is-aUDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory