About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:protein-glutamine gamma-glutamyltransferase activity
Synonym: factor XIIIa
Synonym: fibrinoligase activity
Synonym: fibrin stabilizing factor
Synonym: glutaminylpeptide gamma-glutamyltransferase activity
Synonym: polyamine transglutaminase activity
Synonym: protein-glutamine:amine gamma-glutamyltransferase
Synonym: R-glutaminyl-peptide:amine gamma-glutamyl transferase activity
Synonym: TGase activity
Synonym: tissue transglutaminase
Synonym: transglutaminase activity
GO id:GO:0003810
Definition:Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring acyl groups
                                        is-atransferase activity, transferring amino-acyl groups
                                                is-aagaritine gamma-glutamyltransferase activity
                                                is-aalanylphosphatidylglycerol synthase activity
                                                is-aarginyltransferase activity
                                                is-aaspartyltransferase activity
                                                is-aD-alanine gamma-glutamyltransferase activity
                                                is-aD-glutamyltransferase activity
                                                is-aeoxin D4 synthase activity
                                                is-agamma-glutamylcyclotransferase activity
                                                is-agamma-glutamyltransferase activity
                                                is-aglutaminyl-peptide cyclotransferase activity
                                                is-aglutathione gamma-glutamylcysteinyltransferase activity
                                                is-aleucyltransferase activity
                                                is-alysyltransferase activity
                                                is-apeptidyltransferase activity
                                                is-aprotein-glutamine gamma-glutamyltransferase activity [GO:0003810] (8 genes, 10 annotations)
                                                is-aprotein-lysine lysyltransferase activity
                                                is-aUDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory