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Tg(Lhx8-icre)1Kess - Head
Recombinase Activity Detail
Allele Information
Allele:
Tg(Lhx8-icre)1Kess
transgene insertion 1, Nicoletta Kessaris 		Driver: Lhx8
Type: Transgenic (Recombinase)
Synonym: Lhx7-Cre
Molecular description: Homologous recombination in bacteria was used to modify a 214 Kb BAC RP23-379E17 containing 130 Kb upstream and 61 Kb downstream of the Lhx8 (Lhx7) gene. The codon-improved Cre recombinase (iCre) containing a nuclear localization signal was fused to the initiation codon of the genes using a PCR-based approach. This was followed by a Simian Virus 40 polyadenylation signal and a Kanamycin resistance cassette that was flanked by FRT sites for the selection of recombinant BACs. BAC recombination was designed to delete the remaining ATG-encoding exon together with 50-200 bp from the downstream intron. Mice were generated by pronuclear injection of the construct into fertilized oocytes. No line number is given.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Lhx8-icre)1Kess activity also observed in:
nervous system
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Images
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J:330767 Fig. 2 J:330767 Fig. sup2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory