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Tg(Crhr2-EGFP/cre)#And - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Crhr2-EGFP/cre)#And
transgene insertion, David J Anderson 		Driver: Crhr2
Type: Transgenic (Recombinase, Reporter)
Synonym: Crfr2a-eGFPCre
Molecular description: A mouse bacterial artificial chromosome (BAC clone RP23-78P13) containing the entire Crfr2 gene was used to generate the final transgene. With the BAC another gene Inmt was disrupted by inserting a bovine growth hormone polyadenylation sequence (BGHpA) cassette into the 5' end of the Inmt gene that removed the start codon. To simultaneously target Crfr2a and suppress expression Crfr2b from the BAC, a cassette containing an eGFPCre fusion gene followed by an SV40pA was inserted into the 5'UTR of the third exon of the Crfr2 gene, and a STOP codon was introduced into exon IV (shared by both a and b splice forms) to terminate translation of any Crfr2b mRNA transcribed from the BAC. Founder information and line numbers were not available. The pound symbol (#) is used when no line is specified and/or lines are pooled.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Crhr2-EGFP/cre)#And activity also observed in:
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Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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04/23/2024
MGI 6.23 		The Jackson Laboratory