Tg(Ins1-cre,-DsRed*T3)#Caoy - Nervous System Recombinase Activity Detail MGI Mouse

Tg(Ins1-cre,-DsRed*T3)#Caoy - Nervous System
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Tg(Ins1-cre,-DsRed*T3)#Caoy
transgene insertion, Yanan Cao

Driver: Ins1
Type: Transgenic (Recombinase, Reporter)

Synonym:

Ins1-Cre-Dsred

Molecular description:

The transgene consists of an 8.5-kb fragment of mouse Ins1 promoter (Ins1; nucleotides -8.5 kb to +12 bp relative to the transcriptional start site), a nuclear location signal fused to the Cre gene fragment, an internal ribosome entry site (IRES) sequence, and a Dsred.T3 cDNA fragment followed by a polyadenylation signal. Seven lines (1-7) were generated with similar expression patterns. The pound symbol (#) is used when no line is specified and/or lines are pooled. Cre expression in different organs was examined by RT-PCR with RNA extracted from pancreatic islets, brain, liver, fat, skeletal muscle, spleen, lungs, small intestine, large intestine, kidney, heart, testes, stomach, and hypothalamus. The results showed the negligible Cre expression in tissues other than islets.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Additional Tissues:

Tg(Ins1-cre,-DsRed*T3)#Caoy activity also observed in:
alimentary system, endocrine system

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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