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Tg(Sprr2f-cre)2Dcas - Reproductive System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Sprr2f-cre)2Dcas
transgene insertion 2, Diego H Castrillon 		Driver: Sprr2f
Type: Transgenic (Recombinase)
Synonym: BAC-Sprr2f-Cre
Molecular description: Using a 189 kb BAC clone (RP23-39I4) containing the entire mouse Sprr2f gene, the cre and neo cassette was inserted into the ATG start codon in exon 2 of the mouse Sprr2f gene via bacterial recombineering method. The neo selection cassette was then excised by transient flippase expression, and the resulting engineered BAC was injected into mouse oocytes for the generation of transgenic founder lines. Five founders had cre insertion, the line 2 was assigned to this transgene in absence of specific line information to distinguish it from Tg(Sprr2f-cre)1Dcas generated by the same creator which showed ectopic cre activity in brain and kidney. This transgene shows specific cre activity only in the uterus and no ectopic expression was observed.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Tissue Information
Reproductive System Other recombinase alleles with activity in Reproductive System tissues:
Images
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J:282812 Fig. 1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory