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Tg(Or4e5-cre)1Hsak - Head
Recombinase Activity Detail
Allele Information
Allele:
Tg(Or4e5-cre)1Hsak
transgene insertion 1, Hitoshi Sakano 		Driver: Or4e5
Type: Transgenic (Recombinase)
Synonym: H-Cre, Olfr1507Cre, Tg-H-Cre, Tg(Olfr1507-cre)1Hsak
Molecular description: Cre recombinase gene is expressed under the control of upstream cis-acting DNA region of the mouse Olfr1507, 2-kb conserved homology region, mouse H element enhancer, which regulates odorant receptor (OR) gene cluster expression and Olfr1507 promoter. Due to the H enhancer activity, the Cre gene, now under the control of the Tg MOR28 promoter, is frequently chosen and activated for transcription in OSNs. The MOR28 promoter cannot be activated when any one of the endogenous OR genes is expressed first, due to OR-mediated negative feedback regulation.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Or4e5-cre)1Hsak activity also observed in:
sensory organs
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory