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Allele Information
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Allele:
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Cdkn1aem3(cre/ERT)Smoc
cyclin dependent kinase inhibitor 1A;
endonuclease-mediated mutation 3, Shanghai Model Organisms Center
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Driver: Cdkn1a
Type: Endonuclease-mediated
(Recombinase)
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Synonym:
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P21-CreER
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Molecular description:
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A CreER cDNA was inserted into the stop codon of the gene. A linker encoding a 2A self-cleaving peptide sequence was inserted upstream of the cre/ERT construct to allow simultaneous expression of CreER and Cdkn1a.
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Find mice (IMSR):
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Mouse Strains:
0 strains available
Cell Lines:
0 lines available
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Tissue Information
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Limbs
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Other recombinase alleles with activity in Limbs tissues:
Acanem2(dre)Smoc,
Acantm1(cre/ERT2)Crm,
Alpltm1(cre)Nagy,
Cacna1htm2.1(cre)Glwn,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Clec11aem3(cre/ERT2)Sjm,
Clutm2(EGFP/cre/ERT2)Wtsi,
Col10a1em1(cre)Bcgen,
Col10a1tm2.1(cre)Ksec,
Col10a1tm3.1(cre/ERT)Ksec,
Col2a1em2(dre)Smoc,
Crybb1em1(icre)Cln,
Ddx4em1(icre)Jobo,
Dmp1tm1(cre)Msue,
E2f1Tg(Wnt1-cre)2Sor,
Emx1tm1(cre)Krj,
En1tm2(cre)Wrst,
Etv5tm1(cre/ERT2)Brst,
Fgf10tm2.1(cre/ERT2)Sbel,
Fgf16tm1.1(cre)Sms,
Fgf18tm2.2(cre/ERT2)Dor,
Fgf8tm3.1(cre/Esr1*)Moon,
Foxg1tm1(cre)Skm,
Gas1em1(icre/ERT2)Nono,
Gli1tm3(cre/ERT2)Alj,
Gt(ROSA)26Sortm1(FLP1)Dym,
H2az2Tg(Wnt1-cre)11Rth,
HhatTg(TFAP2A-cre)1Will,
Hic1tm2.1(cre/ERT2)Tmun,
Hoxa11em1(cre/ERT2)Dmwe,
Hoxa13tm1.1(cre/ERT2)Mtor,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Ifi208Tg(Cspg4-cre)1Akik,
Ihhem1(Tomm20/mKate2,dre)Xya,
Islrtm2.1(cre/ERT2)Mat,
Kittm1.1(cre)Jmol,
Krt17tm1(cre)Murr,
Krt6aem1(icre)Vk,
Leprem4(dre/ERT2)Smoc,
Lhx9tm1.1(cre/ERT2)Gan,
Lmx1btm2(cre/ERT2)Rjo,
Meis1tm3.1(cre/ERT2)Mtor,
Meox1tm1(cre)Jpa,
Mnx1tm4(cre)Tmj,
Mrgprdtm1.1(cre/ERT2)Wql,
Myf5tm1.1(cre/Esr1*)Trdo,
Myf5tm1.1(cre)Mrc,
Myf5tm1(cre/Esr1*)Trdo,
Myf5tm1(cre)Mrc,
Myf5tm3(cre)Sor,
Myf6tm1.1(cre/ERT2)Lepr,
Myl1tm1.1(cre/ERT2)Lepr,
Myocdtm1(cre)Dzw,
Myocdtm1(cre)Jomm,
Myod1tm1.1(cre/ERT2)Lepr,
Myod1tm2.1(icre)Glh,
Myogtm1.1(cre/ERT2)Lepr,
Nkx3-2tm3.1(cre)Tlu,
Nkx3-2tm4.1(cre)Tlu,
Notch1tm3(cre)Rko,
Osr2tm2(cre)Jian,
Pax3tm1.1(cre/ERT2)Lepr,
Pax3tm1(cre)Joe,
Pax7tm1(cre/ERT2)Gaka,
Pax7tm1(cre/Esr1*)Cklr,
Pax7tm1(cre)Mrc,
Pax7tm2.1(cre/ERT2)Fan,
Pbx3tm1(EGFP/cre/ERT2)Wtsi,
Pdgfratm1.1(EGFP/cre/ERT2)Hyma,
Piezo2tm1.1(cre)Apat,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Prdm1tm3(icre)Rob,
Prdm1tm5.1(cre/ERT2)Rob,
Scxtm1.1(cre)Shuk,
Shhtm1(EGFP/cre)Cjt,
Shhtm2(cre/ERT2)Cjt,
Shroom3Gt(ROSA53)Sor,
Six1tm1(cre)Xli,
Slc17a6tm2(cre)Lowl,
Sp7tm1(icre)Bcgen,
Sptbtm2(EGFP/cre/ERT2)Wtsi,
Taglntm2(cre)Yec,
Tbx3em1(cre/ERT2)Toyo,
Tcf7l1tm1.1(cre/ERT2)Hng,
Tcf7l2tm3.1(cre/ERT2)Mrc,
Tekem1(dre)Bzsh,
Tg(Acan-cre/ERT2,-luc)1Gbg,
Tg(Acp5-cre)3Rda,
Tg(Acp5-cre)4Rda,
Tg(ACTA1-cre)1Mll,
Tg(ACTA1-cre)79Jme,
Tg(ACTA1-cre/ERT2)97.16Mtz,
Tg(ACTA1-cre/Esr1*)2Kesr,
Tg(ACTA1-rtTA,tetO-cre)102Monk,
Tg(Acta2-cre/ERT2)1Ikal,
Tg(Alx4-cre/ERT2)1Bky,
Tg(Bmx-cre/ERT2)1Rha,
Tg(CAG-cre/Esr1*)1Lbe,
Tg(CAG-cre/Esr1*)5Amc,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(CDX2-cre)101Erf,
Tg(Col10a1-cre)1427Vdm,
Tg(Col10a1-cre)1465Vdm,
Tg(Col10a1-cre)1466Vdm,
Tg(Col10a1-cre)1Xya,
Tg(Col10a1-cre)#Ksec,
Tg(Col11a2-cre)4Nhzi,
Tg(Col1a1-cre)1Bek,
Tg(Col1a1-cre)1Kry,
Tg(Col1a1-cre)2Bek,
Tg(Col1a1-cre/ERT2)1Crm,
Tg(Col1a1-cre/Esr1*)1Mis,
Tg(Col1a1-cre)#Xya,
Tg(Col1a2-cre)23Angl,
Tg(Col1a2-cre/ERT,-ALPP)7Cpd,
Tg(Col2a1-cre)10Amc,
Tg(Col2a1-cre)15Amc,
Tg(Col2a1-cre)1Asz,
Tg(Col2a1-cre)1Bhr,
Tg(Col2a1-cre)1Rsjo,
Tg(Col2a1-cre)1Xya,
Tg(Col2a1-cre)3Amc,
Tg(Col2a1-cre/ERT)1Flng,
Tg(Col2a1-cre/ERT2)1Dic,
Tg(Col2a1-cre/ERT)KA3Smac,
Tg(Col2a1-rtTA,tetO-cre)22Pjro,
Tg(Colq-cre)#Kohno,
Tg(Ctgf-cre)2Aibs,
Tg(Ctsk-cre)1Rda,
Tg(Ctsk-cre)8Rda,
Tg(Cyp39a1-cre)1Aibs,
Tg(Ddx4-cre)1Dcas,
Tg(Dkk3-cre/ERT2)#Mpac,
Tg(Dll1-cre)33Dchp,
Tg(dlx5a-cre)1Mekk,
Tg(Dmp1-cre)1Jqfe,
Tg(EIIa-cre)C5379Lmgd,
Tg(Eno2-cre)39Jme,
Tg(Etv2-cre/ERT2)#Djg,
Tg(Fabp4-cre)1Rev,
Tgfb3tm1(cre)Vk,
Tg(Frzb-cre)1Tylz,
Tg(Gata1-icre)1Jtp,
Tg(Gdf5-cre,-ALPP)1Kng,
Tg(Gdf5-cre/ERT2)#Mpac,
Tg(GDF6-cre/ERT2)L2Kng,
Tg(Gfap-cre)73.12Mvs,
Tg(GH1-cre)1Sac,
Tg(Ghrhr-cre)3242Lsk,
Tg(Grem1-cre/ERT)3Tcw,
Tg(Hand2-cre)7-1Clou,
Tg(Hoxb6-cre/ERT)1Smac,
Tg(Hspa2-cre)1Eddy,
Tg(I12b-cre)1Jlr,
Tg(KRT14-cre)1Amc,
Tg(KRT5-cre)5132Jlj,
Tg(Lbx1-cre)3Cbm,
Tg(Lepr-cre/ERT2)#Cya,
Tg(Lepr-cre/ERT2)#Rha,
Tg(Mef2c-cre)1Blk,
Tg(mI56i-cre)6-2Clou,
Tg(Mnx1-cre/ERT2)8Rbro,
Tg(Msx2-cre)5Rem,
Tg(Msx2-cre/ERT2)2Nono,
Tg(Msx2-cre/ERT)27Alj,
Tg(Myh7-cre)1Zli,
Tg(Myl1-cre)13Nros,
Tg(MYOD1-cre)M23Glh,
Tg(Myog-cre)1Eno,
Tg(Osr1-cre)4Mrt,
Tg(Pax3-cre)2Joe,
Tg(Pdgfrb-cre/ERT2)6096Rha,
Tg(Pf4-icre)Q3Rsko,
Tg(Pitx2-cre/Esr1*)#Hmd,
Tg(Pitx3-cre/ERT2)1Yqd,
Tg(Plp1-cre/ERT2)1Ueli,
Tg(Pou3f4-cre)32Cren,
Tg(POU3F4-cre)M51Cren,
Tg(Prdm1-cre)1Masu,
Tg(Prg4-cre/ERT2)#Mpac,
Tg(Prg4-cre/ERT2)#Ndy,
Tg(Prg4-cre)#Mkaz,
Tg(Prrx1-cre)1Cjt,
Tg(Prrx1-cre/ERT2)1Mlgn,
Tg(Prrx1-mTFP1,-cre/ERT2)1Etnka,
Tg(Pthlh-cre/ERT2)909Nono,
Tg(Rarb-cre)1Bhr,
Tg(Rarb-cre)1Mrc,
Tg(Relb-cre)53Rie,
Tg(Rr162136-cre/ERT2)#Bpou,
Tg(Rr437-cre)#Hmd,
Tg(Rr457-cre/Esr1*)7Hmd,
Tg(Runx2-icre)1Jtuc,
Tg(S100b-EGFP/cre/ERT2)22Amc,
Tg(Scx-cre)HShuk,
Tg(Scx-cre)LShuk,
Tg(Sim1-cre)1Lowl,
Tg(Six1-cre)2Kwk,
Tg(Smad7-cre)1Sjc,
Tg(Sp7-cre/ERT2)#Hmk,
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc,
Tg(Tagln-cre)1Her,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tbx18-icre)3Fech,
Tg(Tbx6-cre)#Rsam,
Tg(T-cre)1Lwd,
Tg(Tek-cre)1Ywa,
Tg(Thy1-cre)1Vln,
Tg(Tyr-cre/ERT2)13Bos,
Tg(Ure2-cre)1Jlr,
Tg(Zp3-cre)3Mrt,
Thtm1(cre)Te,
Tppp3tm1.1(icre/ERT2)Fan,
Trpv4em1(cre/ERT2)Amc,
Twist2tm1.1(cre)Dor,
Twist2tm1(cre)Dor,
Twist2tm1(cre/ERT2)Eno,
Wt1tm1(EGFP/cre)Wtp
(less)
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Images
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J:278880
Fig. 1
J:278880
Fig. S2
J:278880
Fig. S3
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Recombinase Activity
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References
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Analysis Tools