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Tg(Slc6a4-cre)208Ito - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Slc6a4-cre)208Ito
transgene insertion 208, Shigeyoshi Itohara 		Driver: Slc6a4
Type: Transgenic (Recombinase)
Synonym: 5-HTTCre Tg208, Tg(Slc6a4-cre)208Rerz
Molecular description: Tg construct was created by modifying the RP23-39F11 mouse BAC clone to insert the nuclear localization signal (NLS) Cre-pA cassette and FRT-Amp-FRT sequence into the translational initiation site of the Slc6a4 gene. The Amp sequence in the obtained BAC construct was removed by flp/FRT recombination in bacteria. The Tg founder mice were generated by microinjection of linearized constructs into C57BL/6 fertilized eggs. At least six lines were generated and two lines (208 and 810) were identified with similar expression patterns.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Slc6a4-cre)208Ito activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:216132 Fig. 1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory