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Tg(Opalin-icre/ERT2)#Rjfl - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Opalin-icre/ERT2)#Rjfl
transgene insertion, Robin JM Franklin 		Driver: Opalin
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Opalin-iCreERT2
Molecular description: The mouse was generated via bacterial artificial chromosome transgenesis using the Opalin genomic bacterial artificial chromosome RP24-510M10. Insertion of the iCreERT2-polyA-frt-Kanamycin-frt cassette was achieved by homologous recombination (with no loss of the genomic bacterial artificial chromosome) in BAC (RPCI24-510M10) immediately after the Opalin initiation codon ATG of the open reading frame of the Opalin sequence. The frt-kanamycin-frt was removed using flippase recombinase. Four founders were generated, three of which expressed the transgene. The one with highest expression was chosen for further experimentation. Line numbers were not indicated. The pound symbol (#) is used when no line is specified and/or lines are pooled.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Opalin-icre/ERT2)#Rjfl activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:255244 Fig. S1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory