Lgr4<tm1.1(cre/ERT2)Npa> - Alimentary System Recombinase Activity Detail MGI Mouse

Lgr4^{tm1.1(cre/ERT2)Npa} - Alimentary System
Recombinase Activity Detail

Allele Information | Tissue Information | Images | Recombinase Activity | References

Allele Information

Allele:

Lgr4^{tm1.1(cre/ERT2)Npa}
leucine-rich repeat-containing G protein-coupled receptor 4; targeted mutation 1.1, Novartis Pharma AG

Driver: Lgr4
Type: Targeted (Inducible, Null/knockout, Recombinase)

Inducer:

tamoxifen

Synonym:

Lgr4ki, Lgr4-mCherry-IRES-CreERT2

Molecular description:

The targeting construct replaced exon 1 following the start codon and 287 bp of intron 1 with an mCherry reporter gene, IRES, inducible cre recombinase fusion (cre/ERT2), polyadenylation sequence and FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. Antibody testing and direct fluorescence failed to detect mCherry. In situ hybridization confirmed the absence of transcript expression in the intestin, skin and kidney.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Tissue Information

Alimentary System

Other recombinase alleles with activity in Alimentary System tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, A4gnt^{tm1.1(cre/ERT2)Niba}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Agrp^tm1(cre)Lowl ...(more)

Images

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J:212415 Fig. S1

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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