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Tg(Neurod1-cre/ERT2)M1Fcal - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Neurod1-cre/ERT2)M1Fcal
transgene insertion M1, Federico Calegari 		Driver: Neurod1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Neurod1-CreERT2
Molecular description: Bacterial artificial chromosome (BAC) library (Source BioScience) was used to obtain a 160 kb BAC (BMQ-305H2) containing the entire mouse Neurod1 gene. This BAC was modified to replace the coding region with a creERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand-binding domain) followed by a frt-flanked neomycin (neo) selection cassette. Four lines were generated: L (low expression), M1 (intermediate expression), M2, H (high expression). This is a representative record for all lines. Transgene expression patterns are consistent with endogenous gene expression.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Neurod1-cre/ERT2)M1Fcal activity also observed in:
alimentary system, head, sensory organs
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory