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Hprt1tm1(TG-cre)1Sasr - Endocrine System
Recombinase Activity Detail
Allele Information
Allele:
Hprt1tm1(TG-cre)1Sasr
hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Samia Selmi-Ruby 		Driver: TG
Type: Targeted (Recombinase)
Synonym: Tg(TG-cre)1Sasr, Thyr-Cre
Molecular description: A construct with a 2 kb bovine thryoglobulin (TG) regulatory region, intron II of the rabbit beta globin gene, nucleus-targeted cre recombinase sequence, and the SV40 polyA site was inserted into an Hprt destination vector which has a homology arm matching the 5' upstream region of Hprt and a 3' homology region containing proximal portions of the Hprt gene. Homologous recombination in ES cells with the proximal exon 3 deletion of Hprt resulted in integration of 1 copy of the transgene and restoration of a functional Hprt gene.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Hprt1tm1(TG-cre)1Sasr activity also observed in:
alimentary system
Tissue Information
Endocrine System Other recombinase alleles with activity in Endocrine System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory