Kit<tm1.1(cre)Jmol> - Alimentary System Recombinase Activity Detail MGI Mouse

Kit^{tm1.1(cre)Jmol} - Alimentary System
Recombinase Activity Detail

Allele Information | Tissue Information | Recombinase Activity | References

Allele Information

Allele:

Kit^{tm1.1(cre)Jmol}
KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1.1, Jeffery D Molkentin

Driver: Kit
Type: Targeted (Null/knockout, Recombinase, Reporter)

Synonym:

Kit^Cre

Molecular description:

A cDNA encoding a cre-IRES-nlsEGFP (cre recombinase separated by an internal ribosomal entry site from the nuclear localized EGFP coding sequence) cassette and an frt-flanked neomycin selection marker were cloned in-frame at the Kit ATG start site in exon 1. Homologous recombination was performed in ES cells which were aggregated with 8-cell embryos to generate chimeras. Chimeras were crossed to knock-in flp-expressing mice to delete the neo marker. Animals produce a bicistronic transcript for production of cre and EGFP proteins.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Kit^{tm1.1(cre)Jmol} activity also observed in:

cardiovascular system, hemolymphoid system, integumental system, limbs ...(more)

Tissue Information

Alimentary System

Other recombinase alleles with activity in Alimentary System tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, A4gnt^{tm1.1(cre/ERT2)Niba}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Agrp^tm1(cre)Lowl ...(more)

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

7 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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