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Thtm1.1(cre/ERT2)Ddg - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Thtm1.1(cre/ERT2)Ddg
tyrosine hydroxylase; targeted mutation 1.1, David Ginty
Driver: Th
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: TH2A-CreER
Molecular description: A T2A cleavage peptide and the cre/ERT2 fusion protein-coding sequence were introduced to the 3'UTR of the mouse Th gene. An FRT-PGK-EM7-NEOpolyA-FRT-loxP cassette was placed downstream of the 3'UTR region. Homologous recombination was achieved in 129S6/SvEvTac-derived embryonic stem cells and resultant chimeric mice were crossed with Flp mice to excise the neomycin cassette.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory