Tg(Ins1-cre)25Utr - Head Recombinase Activity Detail MGI Mouse

Tg(Ins1-cre)25Utr - Head
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Tg(Ins1-cre)25Utr
transgene insertion 25, Ken-ichi Yagami

Driver: Ins1
Type: Transgenic (Recombinase)

Synonym:

BAC Ins1-cre25

Molecular description:

The targeting vector contained homology arms flanking a nuclear localization signal (NLS) fused to a fragment encoding cre recombinase with a polyadenylation signal. Red/ET recombination in bacterial cells inserted the NLS-cre sequence at the translation initiation site in exon 2 of the Ins1 gene located in a BAC (RP23-181I21). The engineered BAC was linearized and injected into pronuclei of fertilized C57BL/6N oocytes. Five founders had the inserted transgnene (#'s 7, 24, 25, 28 and 32). Line 25 was used further as recombinase reporter activity in the pancreas in F1 crosses was greater than that from other founders.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Tg(Ins1-cre)25Utr activity also observed in:
alimentary system, endocrine system, renal & urinary system, reproductive system

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

7 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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