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Tg(Tshb-cre)4Sac - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Tshb-cre)4Sac
transgene insertion 4, Sally A Camper 		Driver: Tshb
Type: Transgenic (Recombinase)
Synonym: Tg(Tshb-cre), Tg(Tshb-cre)4Sac
Molecular description: Recombineering methods generated a construct in which a cre recombinase cassette was inserted at the transcriptional start site of Tshb in a BAC. Microinjection of the construct generated 4 cre-expressing founders which were crossed to reporter mice for activity analyses. Three lines demonstrated moderate levels of activity in the pituitary gland, but the activity was not specific to thyrotrophs. The other founder line 4 showed higher activity with greater thyrotroph specificity and was selected for further analysis.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Tshb-cre)4Sac activity also observed in:
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory