Cdh6<tm1.1(cre/ERT2)Jrs> - Head Recombinase Activity Detail MGI Mouse

Cdh6^{tm1.1(cre/ERT2)Jrs} - Head
Recombinase Activity Detail

Allele Information | Tissue Information | Images | Recombinase Activity | References

Allele Information

Allele:

Cdh6^{tm1.1(cre/ERT2)Jrs}
cadherin 6; targeted mutation 1.1, Joshua R Sanes

Driver: Cdh6
Type: Targeted (Inducible, Null/knockout, Recombinase)

Inducer:

tamoxifen

Synonym:

Cdh6-CreER, Cdh6^{tm1(cre/ERT)Jrs}

Molecular description:

The targeting vector contained (from 5' to 3') a cDNA sequence encoding the CreER fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain) with N-terminal 6xMyc tag, followed by an FRT-flanked SV40-neo selection cassette. This was inserted into the translational start site in the first coding exon of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette. Mice were crossed to reporter animals for analysis.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Cdh6^{tm1.1(cre/ERT2)Jrs} activity also observed in:
sensory organs

Tissue Information

Head

Other recombinase alleles with activity in Head tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Acan^{tm1(cre/ERT2)Crm}, Acsm4^tm1(cre)Hsak ...(more)

Images

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J:190967 Fig. 6

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

11 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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