Axin2<tm1(cre/ERT2)Rnu> - Integumental System Recombinase Activity Detail MGI Mouse

Axin2^{tm1(cre/ERT2)Rnu} - Integumental System
Recombinase Activity Detail

Allele Information | Tissue Information | Images | Recombinase Activity | References

Allele Information

Allele:

Axin2^{tm1(cre/ERT2)Rnu}
axin 2; targeted mutation 1, Roel Nusse

Driver: Axin2
Type: Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

Axin2^creERT2

Molecular description:

A cre/ERT2 sequence (cre recombinase fused to a G400V/M543A/L544A triple mutation ofthe human estrogen receptor ligand binding domain) and an FRT-flanked puromycin resistance cassette were knocked into exon 2 of the Axin2 gene. Transient flp expression in ES cells and crosses to flp-expressing strains were unsuccessful at excising the selection cassette, but its presence does not seem to have negative side effects.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Tissue Information

Integumental System

Other recombinase alleles with activity in Integumental System tissues:

Agrp^tm1(cre)Lowl, Aire^tm3(cre)Mmat, Alpl^tm1(cre)Nagy, Atoh8^{tm1(EGFP/cre)Gasa} ...(more)

Images

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J:269510 Fig. 6

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

50 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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