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Dlx1tm1(cre/ERT2)Zjh - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Dlx1tm1(cre/ERT2)Zjh
distal-less homeobox 1; transgene insertion 1, Z Josh Huang
Driver: Dlx1
Type: Targeted (knock-in)
Inducer: induced by tamoxifen
Synonym: Dlx1-CreER, Dlx1-CreER-KI, Dlx1-CreERT2, Dlx1-CreERT2-KI
Molecular description: A targeting vector was designed to insert a CreERT2 fusion gene, an SV40 polyA signal, and an frt-flanked neo cassette into the initiation codon of the distal-less homeobox 1 locus (Dlx1). The construct was electroporated into (C57BL/6 x 129S4Sv/Jae)-derived V6.5 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts and chimeric mice were bred with C57BL/6 mice to originate the colony. The mutation is predicted to result in a null allele. Tamoxifen-inducible Cre recombinase activity recapitulates the endogenous Dlx1 expression pattern, Following tamoxifen administration, Cre recombinase activity is observed in Dlx1 positive cortical GABAergic neurons, striatal neurons, and olfactory neurons.
Find mice (IMSR): Mouse Strains: 1 lines available       Cell Lines: 0 lines available
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory