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Notch1tm5(cre/ERT2)Rko - Alimentary System
Recombinase Activity Detail
Allele Information
Allele:
Notch1tm5(cre/ERT2)Rko
notch 1; targeted mutation 5, Raphael Kopan 		Driver: Notch1
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: N1::CreERT2, NIP1::CreERT2, Notch1::CreERT2
Molecular description: The targeting construct was designed to replace exons 29-34 (encoding the intracellular domain) with a CreERT2 sequence and nuclear localization signal, followed immediately downstream by a C-terminal 6xMyc epitope tag, 2xSV40 polyadenylation sequence, and frt-flanked Pgk1/EM7 promoter-driven neomycin selection cassette. The CreER fusion gene (Cre-ERT2) is Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Tissue Information
Alimentary System Other recombinase alleles with activity in Alimentary System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory