About   Help   FAQ
Myt1tm1(EGFP/icre)Ldh - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Myt1tm1(EGFP/icre)Ldh
myelin transcription factor 1; targeted mutation 1, Lynn D Hudson 		Driver: Myt1
Type: Targeted (Recombinase)
Synonym:
Molecular description: A targeting vector was designed to disrupt exon 2 with a fusion of EGFP and the modified Cre-recombinase, iCre , followed by a loxP site, and an frt-flanked neomycin (neo) resistance cassette. The vector also changed the initiation codon at the beginning of exon 2 to a GTG to ensure translation of the EGFP/iCre fusion protein. The neomycin cassette was removed by crossing mice with a transgenic strain expressing Tg(ACTFLPe)9205Dym leaving a single frt site and a loxP site downstream of the EGFP/iCre fusion. Northern blot confirmed the absence of mRNA. At E18, fluorescent cells are distributed throughout the spinal cord.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
Drag images to compare to others or to data in the table below. Drag corners to resize images for more detail. Reset Images
J:324832 Fig. 4 J:324832 Fig. S3
Recombinase Activity
Click heading to re-sort table.
Assays Genotypic Background Result Notes  
References
All for this allele: 3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory