Ret<tm2(cre/ERT2)Ddg> - Nervous System Recombinase Activity Detail MGI Mouse

Ret^{tm2(cre/ERT2)Ddg} - Nervous System
Recombinase Activity Detail

Allele Information | Tissue Information | Recombinase Activity | References

Allele Information

Allele:

Ret^{tm2(cre/ERT2)Ddg}
ret proto-oncogene; targeted mutation 2, David D Ginty

Driver: Ret
Type: Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

Ret^CreER, Ret^CreERT2, Ret-CreERT2, Ret^ERT2

Molecular description:

The first exon of the Ret gene was targeted for homologous recombination. A sequence encoding inducible cre/ERT2, followed by a loxP-flanked AC-Cre Tn5-neo self-excising cassette, was targeted to exon 1 of Ret in ES cells. Following excision of the floxed neo cassette, a line of knockin mice expressing cre/ERT2 was generated. Spatial and temporal expression patterns of the inducible cre recapitulated Ret expression.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Tissue Information

Nervous System

Other recombinase alleles with activity in Nervous System tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Acsm4^tm1(cre)Hsak, Adcyap1r1^{tm1.1(cre/GFP)Rpa} ...(more)

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

35 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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