Tg(Slc1a3-cre/ERT2)45-72Fwp - Liver & Biliary System Recombinase Activity Detail MGI Mouse

Tg(Slc1a3-cre/ERT2)45-72Fwp - Liver & Biliary System
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Tg(Slc1a3-cre/ERT2)45-72Fwp
transgene insertion 45-72, Frank W Pfrieger

Driver: Slc1a3
Type: Transgenic (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

Glast-CreER^T2, GLAST::CreERT2, Tg(Glast-CreER^T2)45-72

Molecular description:

The creER^T2 expression cassette, preceded by a rabbit beta-globin DNA encompassing intron 2 (beta-globin intervening sequences [bGIVS]) and followed by the SV40 polyA signal and a PGK/Tn5-driven neomycin resistance cassette flanked by FRT sites (neo) was inserted by homologous recombination at the transcription initiation site of the Slc1a3 (Glast) gene located in BAC RP23-63O21. The linearized vector was injected into pronuclei of fertilized FVB/N eggs. Line 45-72 showed the highest level of Cre expression, which corresponded to the strong presence of Slc1a3 transcripts. Other regions of the CNS also contained CreER^T2 transcripts, but at lower levels. CreER^T2 mRNA was also detected in the skin and testis in agreement with elevated Slc1a3 transcript levels in these tissues.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Tg(Slc1a3-cre/ERT2)45-72Fwp activity also observed in:
head, muscle, nervous system, respiratory system, sensory organs

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

19 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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