Tg(Ins1-cre/ERT)1Lphi - Reproductive System Recombinase Activity Detail MGI Mouse

Tg(Ins1-cre/ERT)1Lphi - Reproductive System
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Tg(Ins1-cre/ERT)1Lphi
transgene insertion 1, Louis Philipson

Driver: Ins1
Type: Transgenic (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

MIP-CreER, MIP-Cre/ERT, MIP-CreERT^1Lphi

Molecular description:

An 8.3 kb fragment of the mouse insulin promoter (Ins1; from nucleotide -8280 to +12 relative to the transcriptional start site) drives cDNA encoding cre recombinase fused to the mutated mouse estrogen receptor ligand-binding domain. A 2.1 kb fragment of the hGH gene was added to function as a transcriptional stop signal. The 12.5 kb construct was purified and microinjected into fertilized pronuclei of CD1 mice. Line 1 was established.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Tg(Ins1-cre/ERT)1Lphi activity also observed in:
alimentary system, endocrine system

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

93 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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