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Tg(BEST1-rtTA,tetO-cre)1Yzl - Sensory Organs
Recombinase Activity Detail
Allele Information
Allele:
Tg(BEST1-rtTA,tetO-cre)1Yzl
transgene insertion 1, Yun-Zheng Le
Driver: BEST1
Type: Transgenic (Inducible, Inserted expressed sequence, Recombinase)
Inducer: induced by doxycycline
Synonym: VMD2-cre
Molecular description: Two transgenic fragments were co-injected to generate the mouse line. One fragment contains a 3 kb human BEST1 promoter fragment driving expression of the tetracycline-inducible transactivator rtTA and the SV40 polyA sequence. The second fragment consists of the tetracycline-responsive regulatory element (tetO) and human cytomegalovirus immediate early enhancer (hCMV) controlling expression of a translationally optimized cre sequence followed by the mouse metallothionein (Mt1) polyadenylation signal. After co-injection into zygotes, 10 founders were obtained with co-integration of both fragments into a single chromosome being observed in all founders. One line demonstrating substantial activity in Muller glial cells was characterized further.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Tissue Information
Sensory Organs Other recombinase alleles with activity in Sensory Organs tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory