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Tg(Slc6a4-cre/ERT2)EZ8Gsat - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Slc6a4-cre/ERT2)EZ8Gsat
transgene insertion EZ8, GENSAT Project at Rockefeller University 		Driver: Slc6a4
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Founder Line EZ8, Tg(Slc6a4-cre/Esr1)8Gsat
Molecular description: This transgene contains the coding sequence for the Cre-ERT2 fusion protein, followed by a polyadenylation signal, inserted into a mouse genomic artificial chromosome (BAC) at the ATG transcription initiation codon of the solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 gene so that expression of the tamoxifen-activated recombinase is driven by the regulatory sequences of the mouse gene. ERT2 is a triply mutated (G400V, M543A, L544A) human estrogen receptor ligand-binding domain that renders the fusion protein highly sensitive to activation by 4-hydroxytamoxifen, but unresponsive to the receptor's native ligands.
Collection: GENSAT
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Slc6a4-cre/ERT2)EZ8Gsat activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:145110 Fig. 3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory