Lhx6<tm1(cre/ERT2)Zjh> - Nervous System Recombinase Activity Detail MGI Mouse

Lhx6^{tm1(cre/ERT2)Zjh} - Nervous System
Recombinase Activity Detail

Allele Information | Tissue Information | Recombinase Activity | References

Allele Information

Allele:

Lhx6^{tm1(cre/ERT2)Zjh}
LIM homeobox protein 6; targeted mutation 1, Z Josh Huang

Driver: Lhx6
Type: Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

Lhx6-CreER, Lhx6-CreERT2, Lhx6 delta neo

Molecular description:

A targeting vector was designed to insert a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), an SV40 polyA signal, and an frt-flanked neo cassette into the initiation codon of the Lhx6 (LIM homeobox protein 6) gene. Mutant mice were bred with Actin-FLPe mice (on a C57BL/6 congenic background) to remove the neo selection cassette. These Lhx6-CreERT2 mice were subsequently bred with wildtype siblings and/or wildtype C57BL/6 mice for at least one generation (and the FLPe transgene was removed)

Collection:

Neuroscience Blueprint cre

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Lhx6^{tm1(cre/ERT2)Zjh} activity also observed in:
head

Tissue Information

Nervous System

Other recombinase alleles with activity in Nervous System tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Acsm4^tm1(cre)Hsak, Adcyap1r1^{tm1.1(cre/GFP)Rpa} ...(more)

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

10 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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