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Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde - Integumental System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde
transgene insertion 10B, Benoit Van den Eynde 		Driver: Tyr
Type: Transgenic (Conditional ready, Inducible, Inserted expressed sequence, Recombinase)
Inducer: tamoxifen
Synonym: Tg(Tyr-cre/ESR1*,-Hras1*,-Trap1a)10BJvde, TiRP-10B
Molecular description: The mouse promoter was used to drive tamoxifen-inducible, melanocyte-specific expression of a floxed cre/ESR1 fusion containing the aminoacid substitution G521R followed out of frame by a constitutively active Hras1 with the G12V amino acid substitution, an IRES, and the mouse cDNA for Trap1a with its polyadenylation signal. Removal of the floxed cre/ERT fusion is required to express downstream genes. Eight founders were generated (TiRP-1-5, TiRP-5-6, TiRP-8/9A, TiRP-8/9B, TiRP-10A, TiRP-10B, TiRP-14 , and TiRP-16) and each contained concatemers of the transgene in head to tail or tail to tail orientations. Cre mediated recombination removes all but one copy of the recombined transgene. Activity for this line is greater in melanocytes in the hair bulbs and is not seen in the brain, eye, spleen, thymus, kidney, liver, heart, or lung.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Tissue Information
Integumental System Other recombinase alleles with activity in Integumental System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory