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Pax7tm2.1(cre/ERT2)Fan - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Pax7tm2.1(cre/ERT2)Fan
paired box 7; targeted mutation 2.1, Chen-Ming Fan 		Driver: Pax7
Type: Targeted (Inducible, Null/knockout, Recombinase)
Inducer: tamoxifen
Synonym: Pax7CE, Pax7Cre-ERT2
Molecular description: Beginning with the Pax7tm1.2Sjc allele in which exon 2 was knocked out leaving a single loxP site, part of exon 1 was replaced with a cre/ERT2 (ESR1) fusion followed by an IRES-DsRed and an frt flanked neo cassette. Germ line, flp mediated recombination removed the neo cassette. The absence of full-length Pax7 protein expression was confirmed by western blot analysis on P10 tibialis anterior muscle extracts. Expression of the fusion cre/ERT2 protein was confirmed by a cross with a reporter line. DsRed fluorescence was not detectable by epifluorescence nor was DsRed protein by immunostaining.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Pax7tm2.1(cre/ERT2)Fan activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:232845 Full Image
Fig. Pax7 adult pituitary gland J:232845 Fig. Pax7 E10.5 dorsal whole mount J:232845 Full Image
Fig. Pax7 E10.5 neural tube J:232845 Fig. Pax7 E10.5 sag view
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 104 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory