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Tg(Il7-cre)CRche - Liver And Biliary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Il7-cre)CRche
transgene insertion C, Ellen R Richie
Driver: Il7
Type: Transgenic (Recombinase)
Synonym: Il7-Cre, IL-7.Cre
Molecular description: A BAC clone (RPCI-295A3) containing the murine Il7 locus and flanking sequences (96 kb 5'and 17 kb 3' of the Il7 locus) was modified by homologous recombination in E. coli to introduce the cre recombinase cDNA and an FRT site-flanked Zeocin resistance gene at nucleotide position 1 of exon 1 in the Il7 mRNA, replacing the open reading frame of exon 1 entirely as well as the first nucleotide of Iintron 1. The recombinant BACs were transformed to the FLP-expressing E. coli strain FLP-294 to remove the Zeocin resistance gene. The linearized BAC was microinjected into pronuclei of fertilized FVB oocytes. 2 lines were established and line C (with 3 copies of the transgene) was characterized further.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Il7-cre)CRche activity also observed in:
alimentary system, hemolymphoid system, integumental system
Tissue Information
Liver And Biliary System Other recombinase alleles with activity in Liver And Biliary System tissues:
Images
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J:149246 Fig. 4a J:149246 Fig. 4b
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory