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Tg(Il7-cre)CRche - Alimentary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Il7-cre)CRche
transgene insertion C, Ellen R Richie 		Driver: Il7
Type: Transgenic (Recombinase)
Synonym: Il7-Cre, IL-7.Cre
Molecular description: A BAC clone (RPCI-295A3) containing the murine Il7 locus and flanking sequences (96 kb 5'and 17 kb 3' of the Il7 locus) was modified by homologous recombination in E. coli to introduce the cre recombinase cDNA and an FRT site-flanked Zeocin resistance gene at nucleotide position 1 of exon 1 in the Il7 mRNA, replacing the open reading frame of exon 1 entirely as well as the first nucleotide of Iintron 1. The recombinant BACs were transformed to the FLP-expressing E. coli strain FLP-294 to remove the Zeocin resistance gene. The linearized BAC was microinjected into pronuclei of fertilized FVB oocytes. 2 lines were established and line C (with 3 copies of the transgene) was characterized further.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Il7-cre)CRche activity also observed in:
hemolymphoid system, integumental system, liver & biliary system, skeletal system
Tissue Information
Alimentary System Other recombinase alleles with activity in Alimentary System tissues:
Images
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J:149246 Fig. 4a J:149246 Fig. 4b
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory