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Hprt1tm10(Ple162-EGFP/cre)Ems - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Hprt1tm10(Ple162-EGFP/cre)Ems
hypoxanthine phosphoribosyltransferase 1; targeted mutation 10, Elizabeth M Simpson 		Driver: PITX3
Type: Targeted (Recombinase, Reporter)
Synonym: Hprt1tm10(mEMS954)Ems, Hprt1tm10(Ple162-EGFPcre;mEMS954)Ems, PITX3-EGFP/cre
Molecular description: The Ple162-EGFPCre transgene (pEMS1148) was designed with the 3636 bp Ple162 minipromoter (PITX3-D; derived from an intronic candidate regulatory region and a segment of the human paired-like homeodomain 3 (PITX3) promoter) upstream of a minimal F5 mutant-frt site, an EGFP/Cre fusion protein (enhanced green fluorescent protein (with mutated stop) and Cre recombinase), a nuclear localization signal, a second minimal frt site, an SV40 early polyA signal, and a human HPRT complementary sequence (containing exon1, intron1, exon2, and part of intron2).
Collection: Pleiades Promoter Project
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Hprt1tm10(Ple162-EGFP/cre)Ems activity also observed in:
embryo-other, head, sensory organs
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:164356 Fig. 4 J:164356 Fig. S6
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory